Professor Orla Hardiman
Professor of Neurology/Head of Academic , Clinical Medicine
Professor of Neurology/Head of Academic , Trinity Inst. of Neurosciences (TCIN)
Publications and Further Research Outputs
Peer-Reviewed Publications
Costello E, Rooney J, Pinto-Grau M, Burke T, Elamin M, Bede P, McMackin R, Dukic S, Vajda A, Heverin M, Hardiman O, Pender N. , Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study. , J Neurol Neurosurg Psychiatry. , 92, (5), 2021, p460-465
Peters, S. and Visser, A.E. and D'Ovidio, F. and Beghi, E. and Chiò, A. and Logroscino, G. and Hardiman, O. and Kromhout, H. and Huss, A. and Veldink, J. and Vermeulen, R. and Van Den Berg, L.H., Associations of Electric Shock and Extremely Low-Frequency Magnetic Field Exposure with the Risk of Amyotrophic Lateral Sclerosis, American Journal of Epidemiology, 188, (4), 2019, p796-805
Nasseroleslami B, Dukic S, Broderick M, Mohr K, Schuster C, Gavin B, McLaughlin R, Heverin M, Vajda A, Iyer PM, Pender N, Bede P, Lalor EC, Hardiman O., Characteristic Increases in EEG Connectivity Correlate With Changes of Structural MRI in Amyotrophic Lateral Sclerosis., Cereb Cortex, 29, (1), 2019, p27 - 41
Cooper-Knock, J. and Moll, T. and Ramesh, T. and Castelli, L. and Beer, A. and Robins, H. and Fox, I. and Niedermoser, I. and Van Damme, P. and Moisse, M. and Robberecht, W. and Hardiman, O. and Panades, M.P. and Assialioui, A. and Mora, J.S. and Basak, A.N. and Morrison, K.E. and Shaw, C.E. and Al-Chalabi, A. and Landers, J.E. and Wyles, M. and Heath, P.R. and Higginbottom, A. and Walsh, T. and Kazoka, M. and McDermott, C.J. and Hautbergue, G.M. and Kirby, J. and Shaw, P.J., Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis, Cell Reports, 26, (9), 2019, p2298-2306.e5
Van Eijk, R.P.A. and Rooney, J. and Hardiman, O. and Van Den Berg, L.H., Two heads are better than one: Benefits of joint models for ALS trials, Journal of Neurology, Neurosurgery and Psychiatry, 2019
Kueffner, R. and Zach, N. and Bronfeld, M. and Norel, R. and Atassi, N. and Balagurusamy, V. and Di Camillo, B. and Chio, A. and Cudkowicz, M. and Dillenberger, D. and Garcia-Garcia, J. and Hardiman, O. and Hoff, B. and Knight, J. and Leitner, M.L. and Li, G. and Mangravite, L. and Norman, T. and Wang, L. and Xiao, J. and Fang, W.-C. and Peng, J. and Yang, C. and Chang, H.-J. and Stolovitzky, G. and Alkallas, R. and Anghel, C. and Avril, J. and Bacardit, J. and Balser, B. and Balser, J. and Bar-Sinai, Y. and Ben-David, N. and Ben-Zion, E. and Bliss, R. and Cai, J. and Chernyshev, A. and Chiang, J.-H. and Chicco, D. and Corriveau, B.A.N. and Dai, J. and Deshpande, Y. and Desplats, E. and Durgin, J.S. and Espiritu, S.M.G. and Fan, F. and Fevrier, P. and Fridley, B.L. and Godzik, A. and GoliÅ"ska, A. and Gordon, J. and Graw, S. and Guo, Y. and Herpelinck, T. and Hopkins, J. and Huang, B. and Jacobsen, J. and Jahandideh, S. and Jeon, J. and Ji, W. and Jung, K. and Karanevich, A. and Koestler, D.C. and Kozak, M. and Kurz, C. and Lalansingh, C. and Larrieu, T. and Lazzarini, N. and Lerner, B. and Lesinski, W. and Liang, X. and Lin, X. and Lowe, J. and Mackey, L. and Meier, R. and Min, W. and Mnich, K. and Nahmias, V. and Noel-Macdonnell, J. and Oâ donnell, A. and Paadre, S. and Park, J. and Polewko-Klim, A. and Raghavan, R. and Rudnicki, W. and Saghapour, E. and Salomond, J.-B. and Sankaran, K. and Sendorek, D. and Sharan, V. and Shiah, Y.-J. and Sirois, J.-K. and Sumanaweera, D.N. and Usset, J. and Vang, Y.S. and Vens, C. and Wadden, D. and Wang, D. and Wong, W.C. and Xie, X. and Xu, Z. and Yang, H.-T. and Yu, X. and Zhang, H. and Zhang, L. and Zhang, S. and Zhu, S., Stratification of amyotrophic lateral sclerosis patients: A crowdsourcing approach, Scientific Reports, 9, (1), 2019
Ryan, M. and ZaldÃvar Vaillant, T. and McLaughlin, R.L. and Doherty, M.A. and Rooney, J. and Heverin, M. and Gutierrez, J. and Lara-Fernández, G.E. and Pita RodrÃguez, M. and Hackembruch, J. and Perna, A. and Vazquez, M.C. and Musio, M. and Ketzoian, C.N. and Logroscino, G. and Hardiman, O., Comparison of the clinical and genetic features of amyotrophic lateral sclerosis across Cuban, Uruguayan and Irish clinic-based populations, Journal of Neurology, Neurosurgery and Psychiatry, 90, (6), 2019, p659-665
McMackin R, Muthuraman M, Groppa S, Babiloni C, Taylor JP, Kiernan MC, Nasseroleslami B, Hardiman O., Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis., Journal of neurology, neurosurgery, and psychiatry, 90, (9), 2019, p1011 - 1020
McMackin R, Dukic S, Broderick M, Iyer PM, Pinto-Grau M, Mohr K, Chipika R, Coffey A, Buxo T, Schuster C, Gavin B, Heverin M, Bede P, Pender N, Lalor EC, Muthuraman M, Hardiman O, Nasseroleslami B, Dysfunction of attention switching networks in amyotrophic lateral sclerosis. , Neuroimage Clin, 22, 2019, p101707-
Visser, A.E. and D'Ovidio, F. and Peters, S. and Vermeulen, R.C.H. and Beghi, E. and Chiò, A. and Veldink, J.H. and Logroscino, G. and Hardiman, O. and Van Den Berg, L.H., Multicentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk, Journal of Neurology, Neurosurgery and Psychiatry, 2019
Dekker, A.M. and Diekstra, F.P. and Pulit, S.L. and Tazelaar, G.H.P. and van der Spek, R.A. and van Rheenen, W. and van Eijk, K.R. and Calvo, A. and Brunetti, M. and Damme, P.V. and Robberecht, W. and Hardiman, O. and McLaughlin, R. and Chiò, A. and Sendtner, M. and Ludolph, A.C. and Weishaupt, J.H. and Pardina, J.S.M. and van den Berg, L.H. and Veldink, J.H., Exome array analysis of rare and low frequency variants in amyotrophic lateral sclerosis, Scientific Reports, 9, (1), 2019
Shefner, J.M. and Cudkowicz, M.E. and Hardiman, O. and Cockroft, B.M. and Lee, J.H. and Malik, F.I. and Meng, L. and Rudnicki, S.A. and Wolff, A.A. and Andrews, J.A., A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2019
Al-Chalabi, A. and Shaw, P. and Leigh, P.N. and Van Den Berg, L. and Hardiman, O. and Ludolph, A. and Aho, V.V. and Sarapohja, T. and KuoppamÀki, M., Oral levosimendan in amyotrophic lateral sclerosis: A phase II multicentre, randomised, double-blind, placebo-controlled trial, Journal of Neurology, Neurosurgery and Psychiatry, 2019
McMackin R, Bede P, Pender N, Hardiman O, Nasseroleslami B., Neurophysiological markers of network dysfunction in neurodegenerative diseases, Neuroimage Clin, 22, 2019, p101706-
Li Hi Shing S, Chipika RH, Finegan E, Murray D, Hardiman O, Bede P, Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease, Front Neurol, 2019
Finegan E, Chipika RH, Li Hi Shing S, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, McLaughlin RL, Pender N, Hardiman O, Bede P, The clinical and radiological profile of primary lateral sclerosis: a population-based study., Journal of Neurology, 2019
Rogers, M. and Boland, B. and Clarke, S. and Craven, A. and Fassbender, C. and Gill, M. and Hardiman, O. and Henshall, D.C. and Lynch, T. and Mitchell, K. and Pender, N. and Rogan, C. and Roche, R.A.P., Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council, European Journal of Neuroscience, 49, (11), 2019, p1362-1370
Tazelaar, G.H.P. and Dekker, A.M. and van Vugt, J.J.F.A. and van der Spek, R.A. and Westeneng, H.-J. and Kool, L.J.B.G. and Kenna, K.P. and van Rheenen, W. and Pulit, S.L. and McLaughlin, R.L. and Sproviero, W. and Iacoangeli, A. and HÌbers, A. and Brenner, D. and Morrison, K.E. and Shaw, P.J. and Shaw, C.E. and Panadés, M.P. and Mora Pardina, J.S. and Glass, J.D. and Hardiman, O. and Al-Chalabi, A. and van Damme, P. and Robberecht, W. and Landers, J.E. and Ludolph, A.C. and Weishaupt, J.H. and van den Berg, L.H. and Veldink, J.H. and van Es, M.A., Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort, Neurobiology of Aging, 74, 2019, p234.e9-234.e15
Ryan, M. and Heverin, M. and McLaughlin, R.L. and Hardiman, O., Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis, JAMA Neurology, 2019
D'Ovidio, F. and Rooney, J.P.K. and Visser, A.E. and Manera, U. and Beghi, E. and Logroscino, G. and Vermeulen, R.C.H. and Veldink, J.H. and Van Den Berg, L.H. and Hardiman, O. and Chiò, A., Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study, Journal of Neurology, Neurosurgery and Psychiatry, 90, (1), 2019, p11-19
Finegan E, Chipika RH, Shing SLH, Hardiman O, Bede P. , Primary lateral sclerosis: a distinct entity or part of the ALS spectrum? , Amyotroph Lateral Scler Frontotemporal Degener. , 2019, p1 - 13
Andrews, J.A. and Cudkowicz, M.E. and Hardiman, O. and Meng, L. and Bian, A. and Lee, J. and Wolff, A.A. and Malik, F.I. and Shefner, J.M., VITALITY-ALS, a phase III trial of tirasemtiv, a selective fast skeletal muscle troponin activator, as a potential treatment for patients with amyotrophic lateral sclerosis: study design and baseline characteristics, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2018, p259-266
Burke, T., Hardiman, O., Pinto-Grau, M, Longergan, K., Heverin, M., Tobin, K., Staines, A. Galvin, M., and Pender, N, , Longitudinal Predictors of Caregiver Burden in Amyotrophic Lateral Sclerosis: A population-based cohort of patient-caregiver dyads., Journal of Neurology , 2018
Ryan, M. and Heverin, M. and Doherty, M.A. and Davis, N. and Corr, E.M. and Vajda, A. and Pender, N. and McLaughlin, R. and Hardiman, O., Determining the incidence of familiality in ALS, Neurology: Genetics, 4, (3), 2018
Byrne RP, Martiniano R, Cassidy LM, Carrigan M, Hellenthal G, Hardiman O, Bradley DG, McLaughlin RL, Insular Celtic population structure and genomic footprints of migration, PLOS Genetics, 14, 2018, pe1007152
Kappos, L. and Bar-Or, A. and Cree, B.A.C. and Fox, R.J. and Giovannoni, G. and Gold, R. and Vermersch, P. and Arnold, D.L. and Arnould, S. and Scherz, T. and Wolf, C. and Wallström, E. and Dahlke, F. and Achiron, A. and Achtnichts, L. and Agan, K. and Akman-Demir, G. and Allen, A.B. and Antel, J.P. and Antiguedad, A.R. and Apperson, M. and Applebee, A.M. and Ayuso, G.I. and Baba, M. and Bajenaru, O. and Balasa, R. and Balci, B.P. and Barnett, M. and Bass, A. and Becker, V.U. and Bejinariu, M. and Bergh, F.T. and Bergmann, A. and Bernitsas, E. and Berthele, A. and Bhan, V. and Bischof, F. and Bjork, R.J. and Blevins, G. and Boehringer, M. and Boerner, T. and Bonek, R. and Bowen, J.D. and Bowling, A. and Boyko, A.N. and Boz, C. and Bracknies, V. and Braune, S. and Brescia Morra, V. and Brochet, B. and Brola, W. and Brownstone, P.K. and Brozman, M. and Brunet, D. and Buraga, I. and Burnett, M. and Buttmann, M. and Butzkueven, H. and Cahill, J. and Calkwood, J.C. and Camu, W. and Cascione, M. and Castelnovo, G. and Centonze, D. and Cerqueira, J. and Chan, A. and Cimprichova, A. and Cohan, S. and Comi, G. and Conway, J. and Cooper, J.A. and Corboy, J. and Correale, J. and Costell, B. and Cottrell, D.A. and Coyle, P.K. and Craner, M. and Cui, L. and Cunha, L. and Czlonkowska, A. and da Silva, A.M. and de Sa, J. and de Seze, J. and Debouverie, M. and Debruyne, J. and Decoo, D. and Defer, G. and Derfuss, T. and Deri, N.H. and Dihenia, B. and Dioszeghy, P. and Donath, V. and Dubois, B. and Duddy, M. and Duquette, P. and Edan, G. and Efendi, H. and Elias, S. and Emrich, P.J. and Estruch, B.C. and Evdoshenko, E.P. and Faiss, J. and Fedyanin, A.S. and Feneberg, W. and Fermont, J. and Fernandez, O.F. and Ferrer, F.C. and Fink, K. and Ford, H. and Ford, C. and Francia, A. and Freedman, M. and Frishberg, B. and Galgani, S. and Garmany, G.P. and Gehring, K. and Gitt, J. and Gobbi, C. and Goldstick, L.P. and Gonzalez, R.A. and Grandmaison, F. and Grigoriadis, N. and Grigorova, O. and Grimaldi, L.M.E. and Gross, J. and Gross-Paju, K. and Gudesblatt, M. and Guillaume, D. and Haas, J. and Hancinova, V. and Hancu, A. and Hardiman, O. and Harmjanz, A. and Heidenreich, F.R. and Hengstman, G.J.D. and Herbert, J. and Herring, M. and Hodgkinson, S. and Hoffmann, O.M. and Hofmann, W.E. and Honeycutt, W.D. and Hua, L.H. and Huang, D. and Huang, Y. and Huang, D. and Hupperts, R. and Imre, P. and Jacobs, A.K. and Jakab, G. and Jasinska, E. and Kaida, K. and Kalnina, J. and Kaprelyan, A. and Karelis, G. and Karussis, D. and Katz, A. and Khabirov, F.A. and Khatri, B. and Kimura, T. and Kister, I. and Kizlaitiene, R. and Klimova, E. and Koehler, J. and Komatineni, A. and Kornhuber, A. and Kovacs, K. and Koves, A. and Kozubski, W. and Krastev, G. and Krupp, L.B. and Kurca, E. and Lassek, C. and Laureys, G. and Lee, L. and Lensch, E. and Leutmezer, F. and Li, H. and Linker, R.A. and Linnebank, M. and Liskova, P. and Llanera, C. and Lu, J. and Lutterotti, A. and Lycke, J. and Macdonell, R. and Maciejowski, M. and Maeurer, M. and Magzhanov, R.V. and Maida, E.-M. and Malciene, L. and Mao-Draayer, Y. and Marfia, G.A. and Markowitz, C. and Mastorodimos, V. and Matyas, K. and Meca-Lallana, J. and Merino, J.A.G. and Mihetiu, I.G. and Milanov, I. and Miller, A.E. and Millers, A. and Mirabella, M. and Mizuno, M. and Montalban, X. and Montoya, L. and Mori, M. and Mueller, S. and Nakahara, J. and Nakatsuji, Y. and Newsome, S. and Nicholas, R. and Nielsen, A.S. and Nikfekr, E. and Nocentini, U. and Nohara, C. and, Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study, The Lancet, 391, (10127), 2018, p1263-1273
Lechtzin, N. and Cudkowicz, M.E. and de Carvalho, M. and Genge, A. and Hardiman, O. and Mitsumoto, H. and Mora, J.S. and Shefner, J. and Van den Berg, L.H. and Andrews, J.A., Respiratory measures in amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 19, (5-6), 2018, p321-330
de Majo, M. and Topp, S.D. and Smith, B.N. and Nishimura, A.L. and Chen, H.-J. and Gkazi, A.S. and Miller, J. and Wong, C.H. and Vance, C. and Baas, F. and ten Asbroek, A.L.M.A. and Kenna, K.P. and Ticozzi, N. and Redondo, A.G. and Esteban-Pérez, J. and Tiloca, C. and Verde, F. and Duga, S. and Morrison, K.E. and Shaw, P.J. and Kirby, J. and Turner, M.R. and Talbot, K. and Hardiman, O. and Glass, J.D. and de Belleroche, J. and Gellera, C. and Ratti, A. and Al-Chalabi, A. and Brown, R.H. and Silani, V. and Landers, J.E. and Shaw, C.E., ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function, Neurobiology of Aging, 71, 2018, p266.e1-266.e10
Nicolas, A. and Kenna, K.P. and Renton, A.E. and Ticozzi, N. and Faghri, F. and Chia, R. and Dominov, J.A. and Kenna, B.J. and Nalls, M.A. and Keagle, P. and Rivera, A.M. and van Rheenen, W. and Murphy, N.A. and van Vugt, J.J.F.A. and Geiger, J.T. and Van der Spek, R.A. and Pliner, H.A. and Shankaracharya and Smith, B.N. and Marangi, G. and Topp, S.D. and Abramzon, Y. and Gkazi, A.S. and Eicher, J.D. and Kenna, A. and Logullo, F.O. and Simone, I.L. and Logroscino, G. and Salvi, F. and Bartolomei, I. and Borghero, G. and Murru, M.R. and Costantino, E. and Pani, C. and Puddu, R. and Caredda, C. and Piras, V. and Tranquilli, S. and Cuccu, S. and Corongiu, D. and Melis, M. and Milia, A. and Marrosu, F. and Marrosu, M.G. and Floris, G. and Cannas, A. and Capasso, M. and Caponnetto, C. and Mancardi, G. and Origone, P. and Mandich, P. and Conforti, F.L. and Cavallaro, S. and Mora, G. and Marinou, K. and Sideri, R. and Penco, S. and Mosca, L. and Lunetta, C. and Pinter, G.L. and Corbo, M. and Riva, N. and Carrera, P. and Volanti, P. and Mandrioli, J. and Fini, N. and Fasano, A. and Tremolizzo, L. and Arosio, A. and Ferrarese, C. and Trojsi, F. and Tedeschi, G. and Monsurrò, M.R. and Piccirillo, G. and Femiano, C. and Ticca, A. and Ortu, E. and La Bella, V. and Spataro, R. and Colletti, T. and Sabatelli, M. and Zollino, M. and Conte, A. and Luigetti, M. and Lattante, S. and Santarelli, M. and Petrucci, A. and Pugliatti, M. and Pirisi, A. and Parish, L.D. and Occhineri, P. and Giannini, F. and Battistini, S. and Ricci, C. and Benigni, M. and Cau, T.B. and Loi, D. and Calvo, A. and Moglia, C. and Brunetti, M. and Barberis, M. and Restagno, G. and Casale, F. and Marrali, G. and Fuda, G. and Ossola, I. and Cammarosano, S. and Canosa, A. and Ilardi, A. and Manera, U. and Grassano, M. and Tanel, R. and Pisano, F. and Mazzini, L. and Messina, S. and D'Alfonso, S. and Corrado, L. and Ferrucci, L. and Harms, M.B. and Goldstein, D.B. and Shneider, N.A. and Goutman, S.A. and Simmons, Z. and Miller, T.M. and Chandran, S. and Pal, S. and Manousakis, G. and Appel, S.H. and Simpson, E. and Wang, L. and Baloh, R.H. and Gibson, S.B. and Bedlack, R. and Lacomis, D. and Sareen, D. and Sherman, A. and Bruijn, L. and Penny, M. and Moreno, C.D.A.M. and Kamalakaran, S. and Allen, A.S. and Boone, B.E. and Brown, R.H. and Carulli, J.P. and Chesi, A. and Chung, W.K. and Cirulli, E.T. and Cooper, G.M. and Couthouis, J. and Day-Williams, A.G. and Dion, P.A. and Gitler, A.D. and Glass, J.D. and Han, Y. and Harris, T. and Hayes, S.D. and Jones, A.L. and Keebler, J. and Krueger, B.J. and Lasseigne, B.N. and Levy, S.E. and Lu, Y.-F. and Maniatis, T. and McKenna-Yasek, D. and Myers, R.M. and Petrovski, S. and Pulst, S.M. and Raphael, A.R. and Ravits, J.M. and Ren, Z. and Rouleau, G.A. and Sapp, P.C. and Sims, K.B. and Staropoli, J.F. and Waite, L.L. and Wang, Q. and Wimbish, J.R. and Xin, W.W. and Phatnani, H. and Kwan, J. and Broach, J. and Arcila-Londono, X. and Lee, E.B. and Van Deerlin, V.M. and Fraenkel, E. and Ostrow, L.W. and Baas, F. and Zaitlen, N. and Berry, J.D. and Malaspina, A. and Fratta, P. and Cox, G.A. and Thompson, L.M. and Finkbeiner, S. and Dardiotis, E. and Hornstein, E. and MacGowan, D.J.L. and Heiman-Patterson, T. and Hammell, M.G. and Patsopoulos, N.A. and Dubnau, J. and Nath, A. and Musunuri, R.L. and Evani, U.S. and Abhyankar, A. and Zody, M.C. and Kaye, J. and Wyman, S.K. and LeNail, A. and Lima, L. and Rothstein, J.D. and Svendsen, C.N. and Van Eyk, J.E. and Maragakis, N.J. and Kolb, Genome-wide Analyses Identify KIF5A as a Novel ALS Gene, Neuron, 97, (6), 2018, p1268-1283.e6
Crockford, C. and Newton, J. and Lonergan, K. and Chiwera, T. and Booth, T. and Chandran, S. and Colville, S. and Heverin, M. and Mays, I. and Pal, S. and Pender, N. and Pinto-Grau, M. and Radakovic, R. and Shaw, C.E. and Stephenson, L. and Swingler, R. and Vajda, A. and Al-Chalabi, A. and Hardiman, O. and Abrahams, S., ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS, Neurology, 91, (15), 2018, pE1370-E1380
Westeneng, H.-J. and Al-Chalabi, A. and Hardiman, O. and Debray, T.P. and van den Berg, L.H., The life expectancy of Stephen Hawking, according to the ENCALS model, The Lancet Neurology, 17, (8), 2018, p662-663
Bede P, Omer T, Finegan E, Chipika RH, Iyer PM, Doherty MA, Vajda A, Pender N, McLaughlin RL, Hutchinson S, Hardiman O., Connectivity-based characterisation of subcortical grey matter pathology in frontotemporal dementia and ALS: a multimodal neuroimaging study., Brain Imaging Behav, 2018, p1 - 19
Visser, A.E. and Rooney, J.P.K. and D'ovidio, F. and Westeneng, H.-J. and Vermeulen, R.C.H. and Beghi, E. and Chiò, A. and Logroscino, G. and Hardiman, O. and Veldink, J.H. and Van Den Berg, L.H. and Tomasoni, A. and Arnaboldi, M. and Valsecchi, M. and Moleri, M. and Poloni, M. and Alimonti, D. and Tagliavini, F. and Redaelli, V. and Fede, B.D. and Bizzozero, I. and Prioni, S. and Van der Kooi, A.J. and Raaphorst, J. and Calvo, A. and Moglia, C. and Casale, F. and Canosa, A. and Manera, U. and Bertuzzo, D. and Mazzini, L. and Bersano, E. and Heverin, M. and Vadja, A. and Pupillo, E. and Comi, G. and Lunetta, C. and Gerardi, F. and Filosto, M. and Cotelli, M.S. and Rinaldi, F. and Chiveri, L. and Guaita, M.C. and Perrone, P. and Mauro, C. and Diamanti, L. and Ferrarese, C. and Tremolizzo, L. and Delodovici, M.L. and Bono, G. and Zecca, C. and Tortelli, R. and Riva, N., Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis, Journal of Neurology, Neurosurgery and Psychiatry, 89, (8), 2018, p797-803
Logroscino, G. and Marin, B. and Piccininni, M. and Arcuti, S. and Chiò, A. and Hardiman, O. and Rooney, J. and Zoccolella, S. and Couratier, P. and Preux, P.-M. and Beghi, E., Referral bias in ALS epidemiological studies, PLoS ONE, 13, (4), 2018
Heiman-Patterson, T.D. and Cudkowicz, M.E. and De Carvalho, M. and Genge, A. and Hardiman, O. and Jackson, C.E. and Lechtzin, N. and Mitsumoto, H. and Silani, V. and Andrews, J.A. and Chen, D. and Kulke, S. and Rudnicki, S.A. and van den Berg, L.H., Understanding the use of NIV in ALS: results of an international ALS specialist survey, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 19, (5-6), 2018, p331-341
Miriam Galvin,Sile Carney, Bernie Corr, Iain Mays, Niall Pender, Orla Hardiman, Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis, · BMJ Open , 8, (1), 2018, pe018721-
Chiò, A. and Mazzini, L. and D'Alfonso, S. and Corrado, L. and Canosa, A. and Moglia, C. and Manera, U. and Bersano, E. and Brunetti, M. and Barberis, M. and Veldink, J.H. and Van Den Berg, L.H. and Pearce, N. and Sproviero, W. and McLaughlin, R. and Vajda, A. and Hardiman, O. and Rooney, J. and Mora, G. and Calvo, A. and Al-Chalabi, A., The multistep hypothesis of ALS revisited, Neurology, 91, (7), 2018, pe635-e642
Westeneng, H.-J. and Debray, T.P.A. and Visser, A.E. and van Eijk, R.P.A. and Rooney, J.P.K. and Calvo, A. and Martin, S. and McDermott, C.J. and Thompson, A.G. and Pinto, S. and Kobeleva, X. and Rosenbohm, A. and Stubendorff, B. and Sommer, H. and Middelkoop, B.M. and Dekker, A.M. and van Vugt, J.J.F.A. and van Rheenen, W. and Vajda, A. and Heverin, M. and Kazoka, M. and Hollinger, H. and Gromicho, M. and Körner, S. and Ringer, T.M. and Rödiger, A. and Gunkel, A. and Shaw, C.E. and Bredenoord, A.L. and van Es, M.A. and Corcia, P. and Couratier, P. and Weber, M. and Grosskreutz, J. and Ludolph, A.C. and Petri, S. and de Carvalho, M. and Van Damme, P. and Talbot, K. and Turner, M.R. and Shaw, P.J. and Al-Chalabi, A. and Chiò, A. and Hardiman, O. and Moons, K.G.M. and Veldink, J.H. and van den Berg, L.H., Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model, The Lancet Neurology, 17, (5), 2018, p423-433
Kapoor, R. and Ho, P.-R. and Campbell, N. and Chang, I. and Deykin, A. and Forrestal, F. and Lucas, N. and Yu, B. and Arnold, D.L. and Freedman, M.S. and Goldman, M.D. and Hartung, H.-P. and Havrdová, E.K. and Jeffery, D. and Miller, A. and Sellebjerg, F. and Cadavid, D. and Mikol, D. and Steiner, D. and Bartholomé, E. and D'Hooghe, M. and Pandolfo, M. and Van Wijmeersch, B. and Bhan, V. and Blevins, G. and Brunet, D. and Devonshire, V. and Duquette, P. and Freedman, M. and Grand'Maison, F. and Jacques, F. and Lapierre, Y. and Lee, L. and Morrow, S. and Yeung, M. and Dufek, M. and Havrdová, E.K. and Kanovsky, P. and Stetkarova, I. and Talabova, M. and Frederiksen, J. and Kant, M. and Petersen, T. and Ravnborg, M. and Sellebjerg, F. and Airas, L. and Elovaara, I. and Eralinna, J.-P. and Sarasoja, T. and Al Khedr, A. and Brassat, D. and Brochet, B. and Camu, W. and Debouverie, M. and Laplaud, D. and Lebrun Frenay, C. and Pelletier, J. and Vermersch, P. and Vukusi, S. and Baum, K. and Berthele, A. and Faiss, J. and Flachenecker, P. and Hohlfeld, R. and Krumbholz, M. and Lassek, C. and Maeurer, M. and Meuth, S. and Ziemssen, T. and Hardiman, O. and McGuigan, C. and Achiron, A. and Karussis, D. and Bergamaschi, R. and Morra, V.B. and Comi, G. and Cottone, S. and Grimaldi, L. and Mancardi, G.L. and Massacesi, L. and Nocentini, U. and Salvetti, M. and Scarpini, E. and Sola, P. and Tedeschi, G. and Trojano, M. and Zaffaroni, M. and Frequin, S. and Hupperts, R. and Killestein, J. and Schrijver, H. and Van Dijl, R. and van Munster, E. and Czarnecki, M. and Drozdowski, W. and Fryze, W. and Hertmanowska, H. and Ilkowski, J. and Kaminska, A. and Klodowska-Duda, G. and Maciejowski, M. and Motta, E. and Podemski, R. and Potemkowski, A. and Rog, T. and Selmaj, K. and Stelmasiak, Z. and Stepien, A. and Tutaj, A. and Zaborski, J. and Boyko, A. and Chefranova, Z. and Evdoshenko, E. and Khabirov, F. and Sivertseva, S. and Yakupov, E. and Alvarez Cermeño, J.C. and Escartin, A. and Fernandez, O.F. and Garcia-Merino, A. and Hernandez Perez, M.A. and Ayuso, G.I. and Lallana, J.M. and Gairin, X.M. and Oreja-Guevara, C. and Saiz Hinarejos, A. and Gunnarsson, M. and Lycke, J. and Martin, C. and Piehl, F. and Roshanisefat, H. and Sundstrom, P. and Duddy, M. and Gran, B. and Harrower, T. and Hobart, J. and Kapoor, R. and Lee, M. and Mattison, P. and Nicholas, R. and Pearson, O. and Rashid, W. and Rog, D. and Sharrack, B. and Silber, E. and Turner, B. and Williams, A. and Woolmore, J. and Young, C. and Bandari, D. and Berger, J. and Camac, A. and Cohan, S. and Conway, J. and Edwards, K. and Fabian, M. and Florin, J. and Freedman, S. and Garwacki, D. and Goldman, M. and Harrison, D. and Herrman, C. and Huang, D. and Javed, A. and Jeffery, D. and Kamin, S. and Katsamakis, G. and Khatri, B. and Langer-Gould, A. and Lynch, S. and Mattson, D. and Miller, T. and Miravalle, A. and Moses, H. and Muley, S. and Napier, J. and Nielsen, A. and Pachner, A. and Pardo, G. and Picone, M. and Robertson, D. and Royal, W. and Sheppard, C. and Thrower, B. and Twyman, C. and Waubant, E. and Wendt, J. and Yadav, V. and Zabad, R. and Zarelli, G., Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension, The Lancet Neurology, 17, (5), 2018, p405-415
Hardiman, O., Global burden of motor neuron diseases: mind the gaps, The Lancet Neurology, 17, (12), 2018, p1030-1031
Pinto-Grau, M., Hardiman, O., & Pender, N. (2018, The Study of Language in the Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder: a Systematic Review of Findings and New Perspectives., Neuropsychology review, 2018, p1 - 18
Van Rheenen, W. and Pulit, S.L. and Dekker, A.M. and Al Khleifat, A. and Brands, W.J. and Iacoangeli, A. and Kenna, K.P. and Kavak, E. and Kooyman, M. and McLaughlin, R.L. and Middelkoop, B. and Moisse, M. and Schellevis, R.D. and Shatunov, A. and Sproviero, W. and Tazelaar, G.H.P. and Van der Spek, R.A.A. and Van Doormaal, P.T.C. and Van Eijk, K.R. and Van Vugt, J. and Basak, A.N. and Blair, I.P. and Glass, J.D. and Hardiman, O. and Hide, W. and Landers, J.E. and Mora, J.S. and Morrison, K.E. and Newhouse, S. and Robberecht, W. and Shaw, C.E. and Shaw, P.J. and Van Damme, P. and Van Es, M.A. and Wray, N.R. and Al-Chalabi, A. and Van den Berg, L.H. and Veldink, J.H., Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis, European Journal of Human Genetics, 26, (10), 2018, p1537-1546
Madill, M. and McDonagh, K. and Ma, J. and Vajda, A. and McLoughlin, P. and O'Brien, T. and Hardiman, O. and Shen, S., Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms, Molecular Brain, 10, (1), 2017
Lefter S, Hardiman O, Ryan A.M, A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland, Neurology, 88, (3), 2017, p304 - 313
Turner, M.R. and Al-Chalabi, A. and Chio, A. and Hardiman, O. and Kiernan, M.C. and Rohrer, J.D. and Rowe, J. and Seeley, W. and Talbot, K., Genetic screening in sporadic ALS and FTD, Journal of Neurology, Neurosurgery and Psychiatry, 88, (12), 2017, p1042-1044
Galvin, M. Gaffney, R. and Corr, B. and Mays, I. and Hardiman, O., From first symptoms to diagnosis of amyotrophic lateral sclerosis: Perspectives of an Irish informal caregiver cohort - A thematic analysis, BMJ Open, 7, (3), 2017, pe014985-
Murray, D. and Hardiman, O. and Campion, A. and Vance, R. and Horgan, F. and Meldrum, D., The effects of a home-based arm ergometry exercise programme on physical fitness, fatigue and activity in Polio survivors: A randomised controlled trial, Clinical Rehabilitation, 31, (7), 2017, p913-925
Taha Omer, Eoin Finegan, Siobhan Hutchinson, Mark Doherty, Alice Vajda, Russell L McLaughlin, Niall Pender, Orla Hardiman, Peter Bede, Neuroimaging patterns along the ALS-FTD spectrum: a multiparametric imaging study, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, (18), 2017, p611-623
Peter Bede, Eoin Finegan, Orla Hardiman, From pneumomyelography to cord tractography: historical perspectives on spinal imaging., Future Neurol, 12, (3), 2017, p121-124
Pinto-Grau M, Costello E, O'Connor S, Elamin M, Burke T, Heverin M, Pender N,, Hardiman O, Assessing behavioural changes in ALS: cross-validation of ALS-specific measures., Journal of Neurology, 2017, p1397 - 1401
Dukic S., Iyer P. M., Mohr K., Hardiman O., Lalor E. C., Nasseroleslami B., Estimation of coherence using the median is robust against EEG artefacts , 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) , Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) , Jeju, South Korea, 2017, 2017, pp3949 - 3952
Margaret O'Brien, Tom Burke, Mark Heverin, Alice Vajda, Russell McLaughlin, John Gibbons, Susan Byrne, Marta Pinto-Grau, Marwa Elamin, Niall Pender, Orla Hardiman, Clustering of neuropsychiatric disease in first-degree and second-degree relatives of patients with amyotrophic lateral sclerosis, JAMA neurology, 74, 2017, p1425-1430
Bigdeli, T.B. and Ripke, S. and Peterson, R.E. and Trzaskowski, M. and Bacanu, S.-A. and Abdellaoui, A. and Andlauer, T.F.M. and Beekman, A.T.F. and Berger, K. and Blackwood, D.H.R. and Boomsma, D.I. and Breen, G. and ButtenschÃ"n, H.N. and Byrne, E.M. and Cichon, S. and Clarke, T.-K. and Couvy-Duchesne, B. and Craddock, N. and De Geus, E.J.C. and Degenhardt, F. and Dunn, E.C. and Edwards, A.C. and Fanous, A.H. and Forstner, A.J. and Frank, J. and Gill, M. and Gordon, S.D. and Grabe, H.J. and Hamilton, S.P. and Hardiman, O. and Hayward, C. and Heath, A.C. and Henders, A.K. and Herms, S. and Hickie, I.B. and Hoffmann, P. and Homuth, G. and Hottenga, J.-J. and Ising, M. and Jansen, R. and Kloiber, S. and Knowles, J.A. and Lang, M. and Li, Q.S. and Lucae, S. and MacIntyre, D.J. and Madden, P.A.F. and Martin, N.G. and McGrath, P.J. and McGuffin, P. and McIntosh, A.M. and Medland, S.E. and Mehta, D. and Middeldorp, C.M. and Milaneschi, Y. and Montgomery, G.W. and Mors, O. and MÃ"ller-Myhsok, B. and Nauck, M. and Nyholt, D.R. and Nöthen, M.M. and Owen, M.J. and Penninx, B.W.J.H. and Pergadia, M.L. and Perlis, R.H. and Peyrot, W.J. and Porteous, D.J. and Potash, J.B. and Rice, J.P. and Rietschel, M. and Riley, B.P. and Rivera, M. and Schoevers, R. and Schulze, T.G. and Shi, J. and Shyn, S.I. and Smit, J.H. and Smoller, J.W. and Streit, F. and Strohmaier, J. and Teumer, A. and Treutlein, J. and Van Der Auwera, S. and Van Grootheest, G. and Van Hemert, A.M. and Völzke, H. and Webb, B.T. and Weissman, M.M. and Wellmann, J. and Willemsen, G. and Witt, S.H. and Levinson, D.F. and Lewis, C.M. and Wray, N.R. and Flint, J. and Sullivan, P.F. and Kendler, K.S., Genetic effects influencing risk for major depressive disorder in China and Europe, Translational Psychiatry, 7, (3), 2017, pe1074-
Burke T, Lonergan K, Pinto-Grau M, Elamin M, Bede P, Madden C, Hardiman O & Pender N., Visual Encoding, Consolidation, and Retrieval in Amyotrophic Lateral Sclerosis: Executive Function as a Mediator, and Predictor of Performance., Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017, p1-9
Galvin M, Ryan P, Maguire S, Heverin M, Madden C, Vajda A, Normand C, Hardiman O, The path to specialist multidisciplinary care in amyotrophic lateral sclerosis: A population- based study of consultations, interventions and costs. , PLoS One, 12, (6), 2017
Schuster C, Hardiman O, Bede P., Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics, BMC Neurol, 17, (1), 2017, p73-
Rooney J, Fogh I, Westeneng HJ, Vajda A, McLaughlin R, Heverin M, Jones A, van Eijk R, Calvo A, Mazzini L, Shaw C, Morrison K, Shaw PJ, Robberecht W, Van Damme P, Al-Chalabi A, van den Berg L, Chiò A, Veldink J, Hardiman O, C9orf72 expansion differentially affects males with spinal onset amyotrophic lateral sclerosis., Journal of neurology, neurosurgery, and psychiatry, 88, (4), 2017, p281 - 281
Rooney, J.P.K. and Visser, A.E. and D'Ovidio, F. and Vermeulen, R. and Beghi, E. and Chio, A. and Veldink, J.H. and Logroscino, G. and Van Den Berg, L.H. and Hardiman, O., A case-control study of hormonal exposures as etiologic factors for ALS in women, Neurology, 89, (12), 2017, p1283-1290
McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH, Project MinE GWAS Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Genetic correlation between amyotrophic lateral sclerosis and schizophrenia., Nature Communications, 2017, p14774
Burke, T Galvin, M. and Pinto-Grau, M. and Lonergan, K. and Madden, C. and Mays, I. and Carney, S. and Hardiman, O. and Pender, N., Caregivers of patients with amyotrophic lateral sclerosis: investigating quality of life, caregiver burden, service engagement, and patient survival, Journal of Neurology, 264, (5), 2017, p898-904
Al-Chalabi, A. and Andersen, P.M. and Chandran, S. and Chio, A. and Corcia, P. and Couratier, P. and Danielsson, O. and de Carvalho, M. and Desnuelle, C. and Grehl, T. and Grosskreutz, J. and HolmÞy, T. and Ingre, C. and Karlsborg, M. and Kleveland, G. and Christoph Koch, J. and Koritnik, B. and KuzmaKozakiewicz, M. and Laaksovirta, H. and Ludolph, A. and McDermott, C. and Meyer, T. and Mitre Ropero, B. and Mora Pardina, J. and Nygren, I. and Petri, S. and Povedano Panades, M. and Salachas, F. and Shaw, P. and Silani, V. and Staaf, G. and Svenstrup, K. and Talbot, K. and Tysnes, O.-B. and Van Damme, P. and van der Kooi, A. and Weber, M. and Weydt, P. and Wolf, J. and Hardiman, O. and van den Berg, L.H., July 2017 ENCALS statement on edaravone, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18, (7-8), 2017, p471-474
Hardiman, O. and van den Berg, L.H., Edaravone: a new treatment for ALS on the horizon?, The Lancet Neurology, 16, (7), 2017, p490-491
Bede P, Hardiman O. , Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration. , . Amyotroph Lateral Scler Frontotemporal Degener, 2017, p1 - 10
Pupillo, E. and Poloni, M. and Bianchi, E. and Giussani, G. and Logroscino, G. and Zoccolella, S. and Chiò, A. and Calvo, A. and Corbo, M. and Lunetta, C. and Marin, B. and Mitchell, D. and Hardiman, O. and Rooney, J. and Stevic, Z. and Bandettini di Poggio, M. and Filosto, M. and Cotelli, M.S. and Perini, M. and Riva, N. and Tremolizzo, L. and Vitelli, E. and Damiani, D. and Beghi, E. and The EURALS Consortium, Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017, p1-8
Dâ Ovidio, F. and Rooney, J.P.K. and Visser, A.E. and Vermeulen, R.C.H. and Veldink, J.H. and Van Den Berg, L.H. and Hardiman, O. and Logroscino, G. and Chiò, A. and Beghi, E. and for the Euro-MOTOR Group, Critical issues in ALS case-control studies: the case of the Euro-MOTOR study, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18, (5-6), 2017, p411-418
Prieto-Fernández E, DÃaz-de Usera A, Baeta M, Núñez C, Chbel F, Nadifi S, Rouault K, Férec C, Hardiman O, Pinheiro F, de Pancorbo M.M, A genetic overview of Atlantic coastal populations from Europe and North-West Africa based on a 17 X-STR panel, Forensic Science International: Genetics, 27, 2017, p167 - 171
Van Der Spek RA, Van Rheenen W, Pulit SL, Kenna KP, Ticozzi N, Kooyman M, McLaughlin RL, Moisse M, Van Eijk KR, Van Vugt JJFA, Andersen P, Nazli Basak A, Blair I, De Carvalho M, Chio A, Corcia P, Couratier P, Drory VE, Glass JD, Hardiman O, Mora JS, Morrison KE, Mitne-Neto M, Robberecht W, Shaw PJ, Panadés MP, Van Damme P, Silani V, Gotkine M, Weber M, Van Es MA, Landers JE, Al-Chalabi A, Van Den Berg LH, Veldink JH; PROJECT MINE ALS SEQUENCING CONSORTIUM., Reconsidering the causality of TIA1 mutations in ALS, Amyotroph Lateral Scler Frontotemporal Degener, 13, 2017, p1-3
Vajda A, McLaughlin RL, Heverin M, Thorpe O, Abrahams S, Al-Chalabi A, Hardiman O, Genetic testing in ALS: A survey of current practices., Neurology, 88, (10), 2017, p991 - 999
Cooper-Knock, J. and Robins, H. and Niedermoser, I. and Wyles, M. and Heath, P.R. and Higginbottom, A. and Walsh, T. and Kazoka, M. and Al Kheifat, A. and Al-Chalabi, A. and Basak, N. and Blair, I. and Dekker, A. and Hardiman, O. and Hide, W. and Iacoangeli, A. and Kenna, K. and Landers, J. and McLaughlin, R. and Mill, J. and Middelkoop, B. and Moisse, M. and Pardina, J.M. and Morrison, K. and Newhouse, S. and Pulit, S. and Shatunov, A. and Shaw, C. and Sproviero, W. and Tazelaar, G. and van Damme, P. and van den Berg, L. and van der Spek, R. and Eijk, K. and van Es, M. and van Rheenen, W. and van Vugt, J. and Veldink, J. and Kooyman, M. and Glass, J. and Robberecht, W. and Gotkine, M. and Drory, V. and Kiernan, M. and Neto, M.M. and Ztaz, M. and Couratier, P. and Corcia, P. and Silani, V. and Chio, A. and de Carvalho, M. and Pinto, S. and Redondo, A.G. and Andersen, P. and Weber, M. and Ticozzi, N. and Ince, P.G. and Hautbergue, G.M. and McDermott, C.J. and Kirby, J. and Shaw, P.J. and Project MinE ALS Sequencing Consortium, Targeted genetic screen in amyotrophic lateral sclerosis reveals novel genetic variants with synergistic effect on clinical phenotype, Frontiers in Molecular Neuroscience, 10, 2017, p370-
Crockford, C.J. and Kleynhans, M. and Wilton, E. and Radakovic, R. and Newton, J. and Niven, E.H. and Al-Chalabi, A. and Hardiman, O. and Bak, T.H. and Abrahams, S., ECAS A-B-C: alternate forms of the Edinburgh Cognitive and Behavioural ALS Screen, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017, p1-8
Dolzhenko E, van Vugt JJFA, Shaw RJ, Bekritsky MA, van Blitterswijk M, Narzisi G, Ajay SS, Rajan V, Lajoie BR, Johnson NH, Kingsbury Z, Humphray SJ, Schellevis RD, Brands WJ, Baker M, Rademakers R, Kooyman M, Tazelaar GHP, van Es MA, McLaughlin R, Sproviero W, Shatunov A, Jones A, Al Khleifat A, Pittman A, Morgan S, Hardiman O, Al-Chalabi A, Shaw C, Smith B, Neo EJ, Morrison K, Shaw PJ, Reeves C, Winterkorn L, Wexler NS; US-Venezuela Collaborative Research Group, Housman DE, Ng CW, Li AL, Taft RJ, van den Berg LH, Bentley DR, Veldink JH, Eberle MA., Detection of long repeat expansions from PCR-free whole-genome sequence data, Genome Res., 27, 2017, p1895-1903
Hardiman, O. and Al-Chalabi, A. and Brayne, C. and Beghi, E. and Van Den Berg, L.H. and Chio, A. and Martin, S. and Logroscino, G. and Rooney, J., The changing picture of amyotrophic lateral sclerosis: Lessons from European registers, Journal of Neurology, Neurosurgery and Psychiatry, 88, (7), 2017, p557-563
Topp, S.D. and Fallini, C. and Shibata, H. and Chen, H.-J. and Troakes, C. and King, A. and Ticozzi, N. and Kenna, K.P. and Soragia-Gkazi, A. and Miller, J.W. and Sato, A. and Dias, D.M. and Jeon, M. and Vance, C. and Wong, C.H. and De Majo, M. and Kattuah, W. and Mitchell, J.C. and Scotter, E.L. and Parkin, N.W. and Sapp, P.C. and Nolan, M. and Nestor, P.J. and Simpson, M. and Weale, M. and Lek, M. and Baas, F. and De Jong, J.M.V. and Ten Asbroek, A.L.M.A. and Redondo, A.G. and Esteban-Pérez, J. and Tiloca, C. and Verde, F. and Duga, S. and Leigh, N. and Pall, H. and Morrison, K.E. and Al-Chalabi, A. and Shaw, P.J. and Kirby, J. and Turner, M.R. and Talbot, K. and Hardiman, O. and Glass, J.D. and De Belleroche, J. and Maki, M. and Moss, S.E. and Miller, C. and Gellera, C. and Ratti, A. and Al-Sarraj, S. and Brown, R.H., Jr. and Silani, V. and Landers, J.E. and Shaw, C.E., Mutations in the vesicular trafficking protein Annexin A11 are associated with amyotrophic lateral sclerosis Bradley N. Smith, Science Translational Medicine, 9, (388), 2017, peaad9157-
Christopher Crockford, Judith Newton, Katie Lonergan, Caoifa Madden, Iain Mays, Meabhdh O'Sullivan, Emmet Costello, Marta Pinto-Grau, Alice Vajda, Mark Heverin, Niall Pender, Ammar Al-Chalabi, Orla Hardiman, Sharon Abrahams, Measuring reliable change in cognition using the Edinburgh Cognitive and Behavioural ALS Screen (ECAS), Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017, p1 - 9
Peter Bede, Parameswaran M. Iyer, Eoin Finegan, Taha Omer, Orla Hardiman, Virtual brain biopsies in amyotrophic lateral sclerosis: diagnostic classification based on in vivo pathological patterns, Neuroimage Clinical, 15, 2017, p653-658
Peschansky, V., Bedlack, R., Quinn, C., (...), Weber, C., Denson, K.H., ALSUntangled 38: L-serine, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18, (1-2), 2017, p148-151
Iyer PM, Mohr K, Broderick M, Gavin B, Burke T, Bede P, Pinto-Grau M, Pender NP, McLaughlin R, Vajda A, Heverin M, Lalor EC, Hardiman O, Nasseroleslami B, Mismatch Negativity as an Indicator of Cognitive Sub-Domain Dysfunction in Amyotrophic Lateral Sclerosis, Frontiers in Neurology, 8, 2017, p395-
Rooney, J.P.K. and Brayne, C. and Tobin, K. and Logroscino, G. and Glymour, M.M. and Hardiman, O., Benefits, pitfalls, and future design of population-based registers in neurodegenerative disease, Neurology, 88, (24), 2017, p2321-2329
Schuster C, Elamin M, Hardiman O, Bede P., The segmental diffusivity profile of amyotrophic lateral sclerosis associated white matter degeneration., Eur J Neurol., 2016, p1-
Rooney J, Heverin M, Vajda A, Burke T, Galvin M, Tobin K, Elamin M, Staines A, Hardiman O, Survival analysis of geospatial factors in the Irish ALS cohort., Amyotrophic lateral sclerosis & frontotemporal degeneration, 2016, p1-6
Martiniano R, Caffell A, Holst M, Hunter-Mann K, Montgomery J, MÃ"ldner G, McLaughlin R.L, Teasdale M.D, Van Rheenen W, Veldink J.H, Van Den Berg L.H, Hardiman O, Carroll M, Roskams S, Oxley J, Morgan C, Thomas M.G, Barnes I, McDonnell C, Collins M.J, Bradley D.G, Genomic signals of migration and continuity in Britain before the Anglo-Saxons, Nature Communications, 7, 2016, 10326-
Fogh I, Lin K, Tiloca C, Rooney J, Gellera C, Diekstra FP, Ratti A, Shatunov A, van Es MA, Proitsi P, Jones A, Sproviero W, Chiò A, McLaughlin RL, Sorarù G, Corrado L, Stahl D, Del Bo R, Cereda C, Castellotti B, Glass JD, Newhouse S, Dobson R, Smith BN, Topp S, van Rheenen W, Meininger V, Melki J, Morrison KE, Shaw PJ, Leigh PN, Andersen PM, Comi GP, Ticozzi N, Mazzini L, D'Alfonso S, Traynor BJ, Van Damme P, Robberecht W, Brown RH, Landers JE, Hardiman O, Lewis CM, van den Berg LH, Shaw CE, Veldink JH, Silani V, Al-Chalabi A, Powell J, Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis., JAMA neurology, 73, (7), 2016, p812-20
Elamin M, Pinto-Grau M, Burke T, Bede P, Rooney J, Oâ Sullivan M, Lonergan K, Kirby E, Quinlan E, Breen N, Vajda A, Heverin M, Pender N, Hardiman O, Identifying behavioural changes in ALS: Validation of the Beaumont Behavioural Inventory (BBI), Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18, (1-2), 2016, p68-73
Valverde L, Illescas M.J, Villaescusa P, Gotor A.M, Garc'a A, Cardoso S, Algorta J, Catarino S, Rouault K, Férec C, Hardiman O, Zarrabeitia M, Jiménez S, Pinheiro M.F, Jarreta B.M, Olofsson J, Morling N, De Pancorbo M.M, New clues to the evolutionary history of the main European paternal lineage M269: Dissection of the Y-SNP S116 in Atlantic Europe and Iberia, European Journal of Human Genetics, 24, (3), 2016, p437 - 441
Pinto-Grau M, Burke T, Lonergan K, McHugh C, Mays I, Madden C, Vajda A, Heverin M, Elamin M, Hardiman O, Pender N, Screening for cognitive dysfunction in ALS: validation of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) using age and education adjusted normative data, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18, (1-2), 2016, p99-106
Foley G, Timonen V, Hardiman O., "I hate being a burden": The patient perspective on carer burden in amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 17, (5-6), 2016, p351 - 357
Janssens A.I.W.A, Ruytings M, Al-Chalabi A, Chio A, Hardiman O, Mcdermott C.J, Meyer T, Mora G, Van Damme P, Van Den Berg L.H, Vanhaecht K, Winkler A.S, Sermeus W, A mapping review of international guidance on the management and care of amyotrophic lateral sclerosis (ALS), Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 17, (5-6), 2016, p325 - 336
Williams K.L, Topp S, Yang S, Smith B, Fifita J.A, Warraich S.T, Zhang K.Y, Farrawell N, Vance C, Hu X, Chesi A, Leblond C.S, Lee A, Rayner S.L, Sundaramoorthy V, Dobson-Stone C, Molloy M.P, Van Blitterswijk M, Dickson D.W, Petersen R.C, Graff-Radford N.R, Boeve B.F, Murray M.E, Pottier C, Don E, Winnick C, McCann E.P, Hogan A, Daoud H, Levert A, Dion P.A, Mitsui J, Ishiura H, Takahashi Y, Goto J, Kost J, Gellera C, Gkazi A.S, Miller J, Stockton J, Brooks W.S, Boundy K, Polak M, Muñoz-Blanco J.L, Esteban-Pérez J, Rábano A, Hardiman O, Morrison K.E, Ticozzi N, Silani V, De Belleroche J, Glass J.D, Kwok J.B.J, Guillemin G.J, Chung R.S, Tsuji S, Brown R.H, GarcÃa-Redondo A, Rademakers R, Landers J.E, Gitler A.D, Rouleau G.A, Cole N.J, Yerbury J.J, Atkin J.D, Shaw C.E, Nicholson G.A, Blair I.P, CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia, Nature Communications, 7, 2016
Foley G, Timonen V, Hardiman O, â I hate being a burdenâ : The patient perspective on carer burden in amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 17, (5-6), 2016, p351 - 357
Galvin M, Corr B, Madden C, Mays I, McQuillan R, Timonen V, Staines A, Hardiman O, Caregiving in ALS - A mixed methods approach to the study of Burden, BMC Palliative Care, 15, (1), 2016, p81-
Al-Chalabi A, Hardiman O, Kiernan M.C, Chiò A, Rix-Brooks B, van den Berg L.H, Amyotrophic lateral sclerosis: moving towards a new classification system, The Lancet Neurology, 15, (11), 2016, p1182 - 1194
Rooney J, Burke T, Vajda A, Heverin M, Hardiman O, What does the ALSFRS-R really measure? A longitudinal and survival analysis of functional dimension subscores in amyotrophic lateral sclerosis, J Neurol Neurosurg Psychiatry, 2016, p1-
Schuster C, Hardiman O, Bede P, Development of an automated MRI-based diagnostic protocol for amyotrophic lateral sclerosis using disease-specific pathognomonic features: A quantitative disease-state classification study, PLoS ONE, 11, (12), 2016, p016733-
Bede P, Iyer PM, Schuster C, Elamin M, Mclaughlin RL, Kenna K, Hardiman O., The selective anatomical vulnerability of ALS: 'disease-defining' and 'disease-defying' brain regions., Amyotroph Lateral Scler Frontotemporal Degener., 2016, p1-10
Burke T, Pinto-Grau M, Lonergan K, Elamin M, Bede P, Costello E, Hardiman O, Pender N, Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study, PLoS One, 11, (8), 2016, pe0160850-
Burke T, Elamin M, Bede P, Pinto-Grau M, Lonergan K, Hardiman O, Pender N, Discordant Performance on the 'Reading the Mind in the Eyes' Test, Based on Disease Onset in Amyotrophic Lateral Sclerosis, Amyotroph Lateral Scler Frontotemporal Degener, 17, (7-8), 2016, p467-472
Tobin K, Gilthorpe MS, Rooney J, Heverin M, Vajda A, Staines A, Hardiman O, Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence., Journal of neurology, 2016
Rooney J, Vajda A, Heverin M, Crampsie A, Tobin K, McLaughlin R, Staines A, Hardiman O, No association between soil constituents and amyotrophic lateral sclerosis relative risk in Ireland., Environmental research, 147, 2016, p102-7
Ludolph A, Drory V, Hardiman O, Nakano I, Ravits J, Robberecht W, Shefner J, A revision of the El Escorial criteria - 2015, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16, (5-6), 2015, p291 - 292
Elamin M, Bede P, Montuschi A, Pender N, Chio A, Hardiman O, Predicting prognosis in amyotrophic lateral sclerosis: a simple algorithm, Journal of Neurology, 262, (6), 2015, p1447-1454
Connolly S, and Galvin M, Hardiman O, End-of-life management in patients with amyotrophic lateral sclerosis, The Lancet Neurology, 14, (4), 2015, p435 - 442
Küffner R, Zach N, Norel R, Hawe J, Schoenfeld D, Wang L, Li G, Fang L, Mackey L, Hardiman O, Cudkowicz M, Sherman A, Ertaylan G, Grosse-Wentrup M, Hothorn T, van Ligtenberg J, Macke JH, Meyer T, Schölkopf B, Tran L, Vaughan R, Stolovitzky G, Leitner ML, Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression., Nat Biotechnol. , 33, (1), 2015, p51 - 57
Burke T, Healy D, Casey P, Hardiman O, Pender N, Atypical social cognitive processing in premotor Huntingtonâ s disease: a single case study, Irish Journal of Psychological Medicine, 2015, p1-6
Stela Lefter, Orla Hardiman, Russell L. McLaughlin, Sinead M. Murphy, Michael Farrell, Aisling M. Ryan, A novel MYH7 Leu1453pro mutation resulting in Laing distal myopathy in an Irish family, Neuromuscular Disorders , 25, (2), 2015, p155 - 160
Bede P, Elamin M, Byrne S, McLaughlin RL, Kenna K, Vajda A, Fagan A, Bradley DG, Hardiman O., Patterns of cerebral and cerebellar white matter degeneration in ALS., J Neurol Neurosurg Psychiatry, 86, (4), 2015, p468-470
Rooney J, Vajda A, Heverin M, Elamin M, Crampsie A, McLaughlin R, Staines A, Hardiman O, Spatial cluster analysis of population amyotrophic lateral sclerosis risk in Ireland., Neurology, 84, (15), 2015, p1537-44
Burke T, Elamin M, Galvin M, Gallagher L, Hardiman O, Pender N, Erratum: Caregiver burden in amyotrophic lateral sclerosis: a cross-sectional investigation of predictors. [J Neurol, (2015) 262, (1526-1532), DOI 10.1007/s00415-015-7746-z], 2015, - 2799
Connolly S, Heslin C, Mays I, Corr B, Normand C, Hardiman O. , Health and social care costs of managing amyotrophic lateral sclerosis (ALS): An Irish perspective, amyotrophic lateral sclerosis and frontotemporal degeneration, 16, (1-2), 2015, p58 - 62
McLaughlin RL, Vajda A, Hardiman O, Heritability of Amyotrophic Lateral Sclerosis: Insights From Disparate Numbers., JAMA neurology, 72, (8), 2015, p857-8
James Rooney, Susan Byrne, Mark Heverin, Katy Tobin, Alison Dick, Colette Donaghy, Orla Hardiman, A multidisciplinary clinic approach improves survival in ALS: a comparative study of ALS in Ireland and Northern Ireland, Journal of Neurology, Neurosurgery, and Psychiatry , 86, 2015, p496-501
McLaughlin L.R, Vajda A, Hardiman O, Heritability of amyotrophic lateral sclerosis insights from disparate numbers, JAMA Neurology, 72, (8), 2015, p857 - 858
Rooney JP, Tobin K, Crampsie A, Vajda A, Heverin M, McLaughlin R, Staines A, Hardiman O, Social deprivation and population density are not associated with small area risk of amyotrophic lateral sclerosis., Environmental research, 142, 2015, p141-7
Bonini NM, Hardiman O., Ataxin-2 expands insight into the ALS clinical spectrum., Neurology, 84, (3), 2015, p224 - 225
Rooney J, Vajda A, Heverin M, Elamin M, Crampsie A, McLaughlin R, Staines A, Hardiman O, Spatial cluster analysis of population amyotrophic lateral sclerosis risk in Ireland, Neurology, 84, (15), 2015, p1537 - 1544
Agosta F, Al-Chalabi A, Filippi M, Hardiman O, Kaji R, Meininger V, Nakano I, Shaw P, Shefner J, Van Den Berg L.H, Ludolph A, The El Escorial criteria: Strengths and weaknesses, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16, (1-2), 2015, p1 - 7
Bradley WG, Stommel EW, Shi X, Torbick NM, Caller TA, Sabel CE, Rooney JP, Staines A, Hardiman O, Spatial cluster analysis of population amyotrophic lateral sclerosis risk in Ireland., Neurology, 85, (20), 2015, p1822-3
Iyer P.M, Egan C, Pinto-Grau M, Burke T, Elamin M, Nasseroleslami B, Pender N, Lalor E.C, Hardiman O, Functional connectivity changes in resting-state EEG as potential biomarker for Amyotrophic Lateral Sclerosis, PLoS ONE, 10, (6), 2015, 012868-
Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O, First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models., Neuropharmacology, 89C, 2015, p193-203
Burke T, Elamin M, Galvin M, Hardiman O, Pender N, Caregiver burden in amyotrophic lateral sclerosis: a cross-sectional investigation of predictors, Journal of Neurology, 262, (6), 2015, p1526 - 1532
P Bede, C Schuster, M Elamin, R Mclaughlin, K Kenna, O Hardiman. , The selective anatomical vulnerability of ALS - "disease-defining" and "disease defying" brain regions., Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 17, (7-8), 2015, p561 - 570
Burke T, Wynne B, O'Brien C, Elamin M, Bede P, Hardiman O, Pender, N, Retrospective Investigations of Practice Effects on Repeated Neuropsychological Measures of Executive Functioning, The Irish Journal of Psychology, (April), 2015
McLaughlin RL, Kenna KP, Vajda A, Bede P, Elamin M, Cronin S, Donaghy CG, Bradley DG, Hardiman O, Second-generation Irish genome-wide association study for amyotrophic lateral sclerosis., Neurobiology of aging, 36, (2), 2015, p1221.e7-13
Galvin M, Madden C, Maguire S, Heverin M, Vajda A, Staines A, Hardiman O, Patient journey to a specialist amyotrophic lateral sclerosis multidisciplinary clinic: an exploratory study., BMC health services research, 15, 2015, p571
Schuster C, Elamin M, Hardiman O, Bede P, Presymptomatic and longitudinal neuroimaging in neurodegeneration: from snapshots to motion picture - a systematic review, J Neurol Neurosurg Psychiatry , 2015
McLaughlin RL, Kenna KP, Vajda A, Heverin M, Byrne S, Donaghy CG, Cronin S, Bradley DG, Hardiman O., Homozygosity mapping in an Irish ALS case-control cohort describes local demographic phenomena and points towards potential recessive risk loci, Genomics , 105, (4), 2015, p237-241
Bede P, Elamin M, Byrne S, Hardiman O, Sexual dimorphism in ALS: exploring gender-specific neuroimaging signatures., Amyotrophic lateral sclerosis & frontotemporal degeneration, 15, (3-4), 2014, p235-43
Ammar Al-Chalabi, Andrea Calvo, Adriano Chio, Shuna Colville, Cathy M Ellis, Orla Hardiman, Mark Heverin, Robin S Howard, Mark H B Huisman, Noa Keren, P Nigel Leigh, Letizia Mazzini, Gabriele Mora, Richard W Orrell, James Rooney, Kirsten M Scott, William J Scotton, Meinie Seelen, Christopher E Shaw, Katie S Sidle, Robert Swingler, Miho Tsuda, Jan H Veldink, Anne E Visser, Leonard H van den Berg, Neil Pearce, Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study, The Lancet Neurology, 13, (11), 2014, p1108 - 1113
Fogh, I., Ratti, A., Gellera, C., (...), Powell, J., Silani, V. , A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis, Human Molecular Genetics, 23, (8), 2014, p2220-2231
Lefter S, Hardiman O, Costigan D, Lynch B, McConville J, Hand CK, Ryan AM., Andersen-tawil syndrome with early fixed myopathy, Journal of Clinical Neuromuscular Disease, 16, (2), 2014, p79-82
Byrne S, Heverin M, Bede P, Elamin M, Hardiman O, Fecundity in ALS., Amyotrophic lateral sclerosis & frontotemporal degeneration, 15, (3-4), 2014, p204-6
Bede P Hardiman O, 23. Lessons of ALS imaging: Pitfalls and future directions - A critical review., Neuroimaging Clinical, (4), 2014, p436 - 444
Foley G, Timonen V, Hardiman O., Acceptance and decision making in amyotrophic lateral sclerosis from a life-course perspective, Qualitative Health Research, 24, (1), 2014, p67 - 77
Smith BN, Ticozzi N, Fallini C, Gkazi AS, Topp S, Kenna KP, Scotter EL, Kost J, Keagle P, Miller JW, Calini D, Vance C, Danielson EW, Troakes C, Tiloca C, Al-Sarraj S, Lewis EA, King A, Colombrita C, Pensato V, Castellotti B, de Belleroche J, Baas F, ten Asbroek AL, Sapp PC, McKenna-Yasek D, McLaughlin RL, Polak M, Asress S, Esteban-Pérez J, Muñoz-Blanco JL, Simpson M; SLAGEN Consortium, van Rheenen W, Diekstra FP, Lauria G, Duga S, Corti S, Cereda C, Corrado L, Sorarù G, Morrison KE, Williams KL, Nicholson GA, Blair IP, Dion PA, Leblond CS, Rouleau GA, Hardiman O, Veldink JH, van den Berg LH, Al-Chalabi A, Pall H, Shaw PJ, Turner MR, Talbot K, Taroni F, García-Redondo A, Wu Z, Glass JD, Gellera C, Ratti A, Brown RH Jr, Silani V, Shaw CE, Landers JE., Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS., Neuron. , 84, (2), 2014, p324 - 331
Fahey C, Byrne S, McLaughlin R, Kenna K, Shatunov A, Donohoe G, Gill M, Al-Chalabi A, Bradley DG, Hardiman O, Corvin AP, Morris DW., Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample., Neurobiol Aging., 35, 2014, p1510.e1-1510.e5
Diekstra FP1, Van Deerlin VM, van Swieten JC, Al-Chalabi A, Ludolph AC, Weishaupt JH, Hardiman O, Landers JE, Brown RH Jr, van Es MA, Pasterkamp RJ, Koppers M, Andersen PM, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, van Damme P, Melki J, Meininger V, Shatunov A, Shaw CE, Leigh PN, Shaw PJ, Morrison KE, Fogh I, Chiò A, Traynor BJ, Czell D, Weber M, Heutink P, de Bakker PI, Silani V, Robberecht W, van den Berg LH, Veldink JH., C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis, Annals of Neurology, 76, (1), 2014, p120 - 123
Bede P, Hardiman O, Subcortical gray matter structures: A future biomarker for amyotrophic lateral sclerosis?, Future Neurology, 9, (2), 2014, p109 - 111
Foley G, Timonen V, Hardiman O., Exerting control and adapting to loss in amyotrophic lateral sclerosis, Social Science & Medicine, 101, 2014, p113 - 119
McLaughlin RL, Kenna KP, Vajda A, Byrne S, Bradley DG, Hardiman O, UBQLN2 mutations are not a frequent cause of amyotrophic lateral sclerosis in Ireland., Neurobiology of aging, 35, (1), 2014, p267.e9-11
Fahey C, Byrne S, McLaughlin R, Kenna K, Shatunov A, Donohoe G, Gill M, Al-Chalabi A, Bradley DG, Hardiman O, Corvin AP, Morris DW, Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample., Neurobiology of aging, 35, (6), 2014, p1510.e1-1510.e5
Foley G, Timonen V, Hardiman O., Understanding psycho-social processes underpinning engagement with services in motor neurone disease: A qualitative study, Palliative Medicine, 28, (4), 2014, p318 - 325
Rooney J, Heverin M, Vajda A, Crampsie A, Tobin K, Byrne S, Staines A, Hardiman O., An Exploratory Spatial Analysis of ALS Incidence in Ireland over 17.5 Years (1995 - July 2013)., PLoS One. , 9, (5), 2014, pe96556-
Elisabetta Pupillo, Paolo Messina, Giorgia Giussani, Giancarlo Logroscino, Stefano Zoccolella, Adriano Chio, Andrea Calvo, Massimo Corbo, Christian Lunetta, Benoit Marin, Douglas Mitchell, Orla Hardiman, James Rooney, Zorica Stevic, Monica Bandettini di Poggio, Massimiliano Filosto, Maria Sofia Cotelli, Michele Perini, Nilo Riva, Lucio Tremolizzo, Eugenio Vitelli, Danira Damiani, and Ettore Beghi and the EURALS Consortium, Physical Activity and Amyotrophic Lateral Sclerosis: A European Population-Based Case-Control Study, Annals of Neurology, 75, (5), 2014, p708 - 716
Bede P, Walsh R, Fagan AJ, Hardiman O., "Sand-watch" spinal cord: a case of inferior cervical spinal cord atrophy. , Journal of Neurology, 2014, p235-7
Foley G, Timonen V, Hardiman O., Why and how do people with motor neurone disease (MND) engage with allied healthcare professionals? Findings from a qualitative study on the service user experience of healthcare services, Physical Therapy Reviews, Rehabilitation and Therapy Research Society 9th Annual Conference, Belfast, June 21 2013, 19, (1), 2014, p47
Authors of Document Lefter, S., Hardiman, O., Ryan, A.M. , Methodology and Design of a National Epidemiological Study on Adult Neuromuscular Disease, Neuroepidemiology, 2014, p123-130
van Doormaal PT, Ticozzi N, Gellera C, Ratti A, Taroni F, Chiò A, Calvo A, Mora G, Restagno G, Traynor BJ, Birve A, Lemmens R, van Es MA, Saris CG, Blauw HM, van Vught PW, Groen EJ, Corrado L, Mazzini L, Del Bo R, Corti S, Waibel S, Meyer T, Ludolph AC, Goris A, van Damme P, Robberecht W, Shatunov A, Fogh I, Andersen PM, D'Alfonso S, Hardiman O, Cronin S, Rujescu D, Al-Chalabi A, Landers JE, Silani V, van den Berg LH, Veldink JH, Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study., Neurobiology of aging, 35, (10), 2014, p2420.e13-4
Bede, Peter Hardiman, Orla, Lessons of ALS imaging: Pitfalls and future directions - A critical review, NeuroImage: Clinical, 4, 2014, p436 - 443
Murray, D, Hardiman, O, Meldrum, D, Assessment of subjective and motor fatigue in Polio survivors, attending a Postpolio clinic, comparison with healthy controls and an exploration of clinical correlates, PHYSIOTHERAPY THEORY AND PRACTICE, 30, (4), 2014, p229-235
Elamin M, Bede P, Byrne S, Jordan N, Gallagher L, Wynne B, O'Brien C, Phukan J, Lynch C, Pender N, Hardiman O, Cognitive changes predict functional decline in ALS: A population-based longitudinal study., Neurology, 2013
Kenna, KP, McLaughlin, RL, Hardiman, O, Bradley, DG, Using Reference Databases of Genetic Variation to Evaluate the Potential Pathogenicity of Candidate Disease Variants, HUMAN MUTATION, 34, (6), 2013, p836-841
Byrne S, Jordan I, Elamin M, Hardiman O, Age at onset of amyotrophic lateral sclerosis is proportional to life expectancy., Amyotrophic lateral sclerosis & frontotemporal degeneration, 14, (7-8), 2013, p604-7
James Rooney., Susan Byrne, Mark Heverin, Bernie Corr, Marwa Elamin, Anthony Staines, Ben Goldacre, Orla Hardiman, Survival Analysis of Irish Amyotrophic Lateral Sclerosis Patients Diagnosed from 1995-2010, PLOS One, 8, (9), 2013
Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos N.A, Sawcer S.J, van Es M, Andersen P.M, Melki J, Meininger V, Hardiman O, Landers J.E, Brown R.H, Shatunov A, Leigh N, Al-Chalabi A, Shaw C.E, Traynor B.J, Chió A, Restagno G, Mora G, Ophoff R.A, Oksenberg J.R, Van Damme P, Compston A, Robberecht W, Dubois B, van den Berg L.H, De Jager P.L, Veldink J.H, de Bakker P.I.W, No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis, Human Molecular Genetics, 23, (7), 2013, p1916 - 1922
Bede P1, Bokde AL, Byrne S, Elamin M, McLaughlin RL, Kenna K, Fagan AJ, Pender N, Bradley DG, Hardiman O., Multiparametric MRI study of ALS stratified for the C9orf72 genotype, Neurology, 81, (4), 2013, p361-369
Byrne S, Heverin M, Elamin M, Walsh C, Hardiman O, Intermediate repeat expansion length in C9orf72 may be pathological in amyotrophic lateral sclerosis., Amyotrophic lateral sclerosis & frontotemporal degeneration, 2013
Kenna, K.P., Mclaughlin, R.L., Hardiman, O., Bradley, D.G., Using Reference Databases of Genetic Variation to Evaluate the Potential Pathogenicity of Candidate Disease Variants, Human Mutation, 34, (6), 2013, p836-841
Kenna KP, McLaughlin RL, Byrne S, Elamin M, Heverin M, Kenny EM, Cormican P, Morris DW, Donaghy CG, Bradley DG, Hardiman O, Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing., Journal of medical genetics, 50, (11), 2013, p776-83
Turner M.R, Hardiman O, Benatar M, Brooks B.R, Chio A, De Carvalho M, Ince P.G, Lin C, Miller R.G, Mitsumoto H, Nicholson G, Ravits J, Shaw P.J, Swash M, Talbot K, Traynor B.J, Van Den Berg L.H, Veldink J.H, Vucic S, Kiernan M.C, Controversies and priorities in amyotrophic lateral sclerosis, The Lancet Neurology, 12, (3), 2013, p310 - 322
P. Bede, A. Bokde, M. Elamin, S. Byrne, R.L. McLaughlin, N. Jordan, H. Hampel, L. Gallagher, C. Lynch, A.J. Fagan, N. Pender, O. Hardiman, Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality, Journal of Neurology, Neurosurgery & Psychiatry, 84, (7), 2013, p766 - 773
Cudkowicz M.E, van den Berg L.H, Shefner J.M, Mitsumoto H, Mora J.S, Ludolph A, Hardiman O, Bozik M.E, Ingersoll E.W, Archibald D, Meyers A.L, Dong Y, Farwell W.R, Kerr D.A, Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): A randomised, double-blind, phase 3 trial, The Lancet Neurology, 12, (11), 2013, p1059 - 1067
Bede P, Elamin M, Byrne S, McLaughlin R, Kenna K, Vajda A, Pender N, Bradley DG, Hardiman O, Basal ganglia involvement in Amyotrophic Lateral Sclerosis, Neurology, 81, 2013, p1 - 9
Factor-Litvak P, Al-Chalabi A, Ascherio A, Bradley W, ChÃo A, Garruto R, Hardiman O, Kamel F, Kasarskis E, McKee A, Nakano I, Nelson L.M, Eisen A, Current pathways for epidemiological research in amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14, (SUPPL1), 2013, p33 - 43
Byrne S, Pradhan F, Ni Dhubhghaill S, Treacy M, Cassidy L, Hardiman O, Blink rate in ALS., Amyotrophic lateral sclerosis & frontotemporal degeneration, 14, (4), 2013, p291-3
Bede, P, Elamin, M, Byrne, S, McLaughlin, RL, Kenna, K, Vajda, A, Pender, N, Bradley, DG, Hardiman, O, Basal ganglia involvement in amyotrophic lateral sclerosis, NEUROLOGY, 81, (24), 2013, p2107-2115
Byrne S, Heverin M, Elamin M, Bede P, Lynch C, Kenna K, McLaughlin R, Walsh C, Al Chalabi A, Hardiman O, Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: a population-based case-control cohort study of familial and sporadic amyotrophic lateral sclerosis., Annals of neurology, 74, (5), 2013, p699-708
Bede, P, Bokde, ALW, Byrne, S, Elamin, M, McLaughlin, RL, Kenna, K, Fagan, AJ, Pender, N, Bradley, DG, Hardiman, O, Multiparametric MRI study of ALS stratified for the C9orf72 genotype, NEUROLOGY, 81, (4), 2013, p361-369
P. Bede, A.L. Bokde, S. Byrne, M. Elamin, A.J. Fagan, O. Hardiman, Spinal cord markers in ALS - diagnostic and biomarker considerations, Amyotrophic Lateral Sclerosis, 13, 2012, p407 - 415
Elamin M, Pender N, Hardiman O, Abrahams S, Social cognition in neurodegenerative disorders: a systematic review., Journal of neurology, neurosurgery, and psychiatry, 83, (11), 2012, p1071-9
Andersen P.M, Abrahams S, Borasio G.D, de Carvalho M, Chio A, Van Damme P, Hardiman O, Kollewe K, Morrison K.E, Petri S, Pradat P.-F, Silani V, Tomik B, Wasner M, Weber M, EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) - revised report of an EFNS task force, European Journal of Neurology, 19, (3), 2012, p360 - 375
Diekstra F.P, Saris C.G.J, van Rheenen W, Franke L, Jansen R.C, van Es M.A, van Vught P.W.J, Blauw H.M, Groen E.J.N, Horvath S, Estrada K, Rivadeneira F, Hofman A, Uitterlinden A.G, Robberecht W, Andersen P.M, Melki J, Meininger V, Hardiman O, Landers J.E, Brown Jr. R.H, Shatunov A, Shaw C.E, Leigh P.N, Al-Chalabi A, Ophoff R.A, van den Berg L.H, Veldink J.H, Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS, PLoS ONE, 7, (4), 2012
Foley G, Timonen V, Hardiman O., Experience of services as a key outcome in amyotrophic lateral sclerosis (ALS) care. The case for a better understanding of patient experiences, American Journal of Hospice and Palliative Medicine, 29, (5), 2012, p362 - 367
Foley G, Timonen V, Hardiman O., Patients' perceptions of services and preferences for care in amyotrophic lateral sclerosis: A review, Amyotrophic Lateral Sclerosis, 13, (1), 2012, p11 - 24
Pupillo E, Messina P, Logroscino G, Zoccolella S, Chiò A, Calvo A, Corbo M, Lunetta C, Micheli A, Millul A, Vitelli E, Beghi E, Bissolati M, Formaglio F, Gerardi F, Giussani G, Lunetta C, Maestri E, Millul A, Prelle A, Protti A, Riva N, Santoro D, Al-Chalabi A, Chiò A, Berro A.C, De Mercanti S, Giacone S, Ilardi A, Hardiman O, Logroscino G, Capozzo R, Zoccolella S, Ludolph A, Mitchell D, Preux P.-M, Swingler R, van den Berg L, Alvisi E, Cereda C, Ceroni M, Citterio A, di Poggio M.B, Caponnetto C, Buzzi P, Colombo I, Corbo M, Cotelli M.S, Filosto M, Micheli A, Padovani A, De Lodovici L, Ferrarese C, Tremolizzo L, Fetoni V, Palazzini E, Guaita M.C, Perrone P, Secchi P, Lorusso L, Sidoti V, Perini M, Tavernelli F, Rigamonti A, Vitelli E, Trauma and amyotrophic lateral sclerosis: A case-control study from a population-based registry, European Journal of Neurology, 19, (12), 2012, p1509 - 1517
Byrne S, Elamin M, Bede P, Shatunov A, Walsh C, Corr B, Heverin M, Jordan N, Kenna K, Lynch C, McLaughlin RL, Iyer PM, O'Brien C, Phukan J, Wynne B, Bokde AL, Bradley DG, Pender N, Al-Chalabi A, Hardiman O, Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study., Lancet neurology, 11, (3), 2012, p232-40
Murray D1, Meldrum D, Moloney R, Campion A, Horgan F, Hardiman O., The effects of a home-based arm ergometry exercise programme on physical fitness, fatigue and activity in polio survivors: Protocol for a randomised controlled trial, BMC Neurology, 12, 2012, p157-
Bedlack R, Hardiman O, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, Dimachkie M, Wang Y, Wicks P, Heywood J, Novella S, Rowland L.P, Pioro E, Kinsley L, Mitchell K, Glass J, Sathornsumetee S, Kwiecinski H, Baker J, Atassi N, Forshew D, Ravits J, Conwit R, Jackson C, Sherman A, Dalton K, Tindall K, Gonzalez G, Robertson J, Phillips L, Benatar M, Sorenson E, Shoesmith C, Nash S, Marigakis N, Moore D, Caress J, Boylan K, Armon C, Grosso M, Gerecke B, Wymer J, Oskarsson B, Bowser R, Drory V, Shefner J, Heiman-Patterson T, Lechtzin N, Leitner M, Miller R, Mitsumoto H, Levine T, Russell J, Sharma K, Saperstein D, McClusky L, MacGowan D, Licht J, Verma A, Strong M, Lomen-Hoerth C, Tandan R, Rivner M, Kolb S, Polak M, Rudnicki S, Kittrell P, Quereshi M, Sachs G, Pattee G, Weiss M, Kissel J, Goldstein J, Rothstein J, Pastula D, ALSUntangled No. 16: Cannabis, Amyotrophic Lateral Sclerosis, 13, (4), 2012, p400 - 404
Hardiman O, Multidisciplinary care in ALS: Expanding the team, Amyotrophic Lateral Sclerosis, 13, (2), 2012, p165-
Hardiman O, Figlewicz D.A, The expansions of ALS, Neurology, 79, (9), 2012, p842 - 843
Bede P, Bokde AL, Byrne S, Elamin M, Fagan AJ, Hardiman O, Spinal cord markers in ALS: Diagnostic and biomarker considerations., Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 13, (5), 2012, p407-15
Foley G, Timonen V, Hardiman O, Experience of services as a key outcome in amyotrophic lateral sclerosis (ALS) care: the case for a better understanding of patient experiences., The American journal of hospice & palliative care, 29, (5), 2012, p362-7
Phukan J, Elamin M, Bede P, Jordan N, Gallagher L, Byrne S, Lynch C, Pender N, Hardiman O, The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study., Journal of neurology, neurosurgery, and psychiatry, 83, (1), 2012, p102-8
Bede P, Bokde A, Elamin M, Byrne S, McLaughlin RL, Jordan N, Hampel H, Gallagher L, Lynch C, Fagan AJ, Pender N, Hardiman O, Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality., Journal of neurology, neurosurgery, and psychiatry, 84, (7), 2012, p766-73
Byrne S, Elamin M, Bede P, Hardiman O, Absence of consensus in diagnostic criteria for familial neurodegenerative diseases., Journal of neurology, neurosurgery, and psychiatry, 83, (4), 2012, p365-7
Hardiman O, Management of respiratory symptoms in ALS., Journal of neurology, 258, (3), 2011, p359-65
Barry H, Hardiman O, Healy D.G, Keogan M, Moroney J, Molnar P.P, Cotter D.R, Murphy K.C, Anti-NMDA receptor encephalitis: An important differential diagnosis in psychosis, British Journal of Psychiatry, 199, (6), 2011, p508 - 509
Beghi E, Pupillo E, Messina P, Giussani G, Chiò A, Zoccolella S, Moglia C, Corbo M, Logroscino G, Al-Chalabi A, Hardiman O, Ludolph A, Mitchell D, Preux P.-M, Swingler R, Traynor B.J, Alvisi E, Cereda C, Ceroni M, Citterio A, di Poggio M.B, Caponnetto C, Bissolati M, Buzzi P, Colombo I, Formaglio F, Lunettam C, Maestri E, Millul A, Prelle A, Protti A, Riva N, Santoro D, Capozzo R, Berro A.C, Cammarosano S, Giacone S, Ilardi A, Cotelli M.S, Filosto M, Micheli A, Padovani A, De Lodovici L, Ferrarese C, Tremolizzo L, Fetoni V, Palazzini E, Guaita M.C, Perrone P, Secchi P, Lorusso L, Sidoti V, Perini M, Tavernelli F, Rigamonti A, Vitelli E, Coffee and amyotrophic lateral sclerosis: A possible preventive role, American Journal of Epidemiology, 174, (9), 2011, p1002 - 1008
Kiernan M.C, Vucic S, Cheah B.C, Turner M.R, Eisen A, Hardiman O, Burrell J.R, Zoing M.C, Amyotrophic lateral sclerosis, The Lancet, 377, (9769), 2011, p942 - 955
Beghi E, Chiò A, Couratier P, Esteban J, Hardiman O, Logroscino G, Millul A, Mitchell D, Preux P.-M, Pupillo E, Stevic Z, Swingler R, Traynor B.J, Van Den Berg L.H, Veldink J.H, Zoccolella S, The epidemiology and treatment of ALS: Focus on the heterogeneity of the disease and critical appraisal of therapeutic trials, Amyotrophic Lateral Sclerosis, 12, (1), 2011, p1 - 10
Geser F, Prvulovic D, O'Dwyer L, Hardiman O, Bede P, Bokde AL, Trojanowski JQ, Hampel H, On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia., Progress in neurobiology, 95, (4), 2011, p649-62
F. Geser, L. O'Dwyer, O. Hardiman, P. Bede, A.L.W. Bokde, D. Prvulovic, John Q. Trojanowski, H. Hampel, On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia, Progress in Neurobiology, 95, (4), 2011, p649-662
Bede P, Oliver D, Stodart J, van den Berg L, Simmons Z, Brannagáin DÓ, Borasio GD, Hardiman O., Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives, BMJ Support Palliat Care, 1, (3), 2011, p343 - 348
Bede P, Bokde AL, Byrne SC, Elamin M, Walsh RJ, Hardiman O, Waterskier's Hirayama syndrome, Journal of Neurology, 258, (11), 2011, p2078 - 2079
Hardiman O, Amyotrophic lateral sclerosis and vascular risk: A metabolic conundrum, Journal of Neurology, Neurosurgery and Psychiatry, 82, (6), 2011, p591-
Byrne S, Bede P, Elamin M, Kenna K, Lynch C, McLaughlin R, Hardiman O, Proposed criteria for familial amyotrophic lateral sclerosis., Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 12, (3), 2011, p157-9
Elamin M, Phukan J, Bede P, Jordan N, Byrne S, Pender N, Hardiman O, Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia., Neurology, 76, (14), 2011, p1263-9
Byrne S, Walsh C, Lynch C, Bede P, Elamin M, Kenna K, McLaughlin R, Hardiman O, Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis., Journal of neurology, neurosurgery, and psychiatry, 82, (6), 2011, p623 - 627
Hardiman O, van den Berg LH, Kiernan MC, Clinical diagnosis and management of amyotrophic lateral sclerosis., Nature reviews. Neurology, 7, (11), 2011, p639-49
Peter Bede, David Oliver, James Stodart, Leonard van den Berg, Zachary Simmons, Doiminic Ó Brannagáin, Gian Domenico Borasio, Orla Hardiman, Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives, Journal of Neurology Neurosurgery and Psychiatry, 82, 2011, p413-418
Shatunov A, Mok K, Newhouse S, Weale M.E, Smith B, Vance C, Johnson L, Veldink J.H, van Es M.A, van den Berg L.H, Robberecht W, Van Damme P, Hardiman O, Farmer A.E, Lewis C.M, Butler A.W, Abel O, Andersen P.M, Fogh I, Silani V, Chiò A, Traynor B.J, Melki J, Meininger V, Landers J.E, McGuffin P, Glass J.D, Pall H, Leigh P.N, Hardy J, Brown R.H, Powell J.F, Orrell R.W, Morrison K.E, Shaw P.J, Shaw C.E, Al-Chalabi A, Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: A genome-wide association study, The Lancet Neurology, 9, (10), 2010, p986 - 994
Blauw H.M, Al-Chalabi A, Andersen P.M, van Vught P.W, Diekstra F.P, van Es M.A, Saris C.G, Groen E.J, van Rheenen W, Koppers M, Slot R.v, Strengman E, Estrada K, Rivadeneira F, Hofman A, Uitterlinden A.G, Kiemeney L.A, Vermeulen S.H, Birve A, Waibel S, Meyer T, Cronin S, McLaughlin R.L, Hardiman O, Sapp P.C, Tobin M.D, Wain L.V, Tomik B, Slowik A, Lemmens R, Rujescu D, Schulte C, Gasser T, Brown Jr. R.H, Landers J.E, Robberecht W, Ludolph A.C, Ophoff R.A, Veldink J.H, van den Berg L.H, A large genome scan for rare CNVs in amyotrophic lateral sclerosis, Human Molecular Genetics, 19, (20), 2010, p4091 - 4099
Logroscino G, Traynor B.J, Hardiman O, Chió A, Mitchell D, Swingler R.J, Millul A, Benn E, Beghi E, Incidence of amyotrophic lateral sclerosis in Europe, Journal of Neurology, Neurosurgery and Psychiatry, 81, (4), 2010, p385 - 390
Phukan J, Ali E, Pender N.P, Molloy F, Hennessy M, Walsh R.J, Hardiman O, Huntington's disease presenting as amyotrophic lateral sclerosis, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 11, (4), 2010, p405 - 407
Tong P, Prendergast JG, Lohan AJ, Farrington SM, Cronin S, Friel N, Bradley DG, Hardiman O, Evans A, Wilson JF, Loftus B, Sequencing and analysis of an Irish human genome., Genome Biology, 11, (9), 2010, pR91
O'Doherty L.J, Hickey A, Hardiman O, Measuring life quality, physical function and psychological well-being in neurological illness, Amyotrophic Lateral Sclerosis, 11, (5), 2010, p461 - 468
Russell Lewis McLaughlin, Julie Phukan, William McCormack, David S. Lynch, Matthew Greenway, Simon Cronin, Jean Saunders, Agnieska Slowik, Barbara Tomik, Peter M. Andersen, Daniel G. Bradley, Phil Jakeman, Orla Hardiman, Angiogenin Levels and ANG Genotypes: Dysregulation in Amyotrophic Lateral Sclerosis, PloS ONE, 5, (11), 2010, pe15402
Donaghy C, Pinnock R, Abrahams S, Cardwell C, Hardiman O, Patterson V, McGivern R.C, Gibson J.M, Slow saccades in bulbar-onset motor neurone disease, Journal of Neurology, 257, (7), 2010, p1134 - 1140
Donaghy C, Clarke J, Patterson C, Kee F, Hardiman O, Patterson V, The epidemiology of motor neuron disease in Northern Ireland using capture-recapture methodology, Amyotrophic Lateral Sclerosis, 11, (4), 2010, p374 - 378
Beghi E, Logroscino G, Chiò A, Hardiman O, Millul A, Mitchell D, Swingler R, Traynor B.J, Amyotrophic lateral sclerosis, physical exercise, trauma and sports: Results of a population-based pilot case-control study, Amyotrophic Lateral Sclerosis, 11, (3), 2010, p289 - 292
Byrne S, Hardiman O, Willful modulation of brain activity in disorders of consciousness., The New England journal of medicine, 362, (20), 2010, p579-589
Zaldivar T, Gutierrez J, Lara G, Carbonara M, Logroscino G, Hardiman O, Reduced frequency of ALS in an ethnically mixed population: A population-based mortality study, Neurology, 72, (19), 2009, p1640 - 1645
Giovannoni G, Barbarash O, Casset-Semanaz F, King J, Metz L, Pardo G, Simsarian J, SÞrensen P.S, Stubinski B, Carra A, Cristiano E, Luetic G, Rodriguez Alfici A, Cruz G, Vetere S, Pollard J, Boundy K, Sedal L, Butzkueven H, MacDonnell R, Metz L.M, Zabad R.K, Soelberg SÞrensen P, Hardiman O, Tubridy N, Karussis D, Achiron A, Vaitkus A, Kizlaitiene R, Lesnyak O, Zaslavsky L, Poverennova I, Sidorov P, Khasanova D, Alifirova V, Casanova B, Balyazin V, Lutsky M, RodrÃguez-AntigÃŒedad A, GarcÃa-Merino J, Arroyo R, Olsson T, Barnes D, Young C, O'Riordan J, Malik O, Armstrong R, Sheppard C, Thrower B, Wray S, Gross J, Wynn D, Miller T, Garmany G, Sherman M, Safety and immunogenicity of a new formulation of interferon β-1a (Rebif® New Formulation) in a Phase IIIb study in patients with relapsing multiple sclerosis: 96-week results, Multiple Sclerosis, 15, (2), 2009, p219 - 228
Hardiman O, Ten years of the ALS journal, Amyotrophic Lateral Sclerosis, 10, (5-6), 2009, p257-
Landers J.E, Melki J, Meininger V, Glass J.D, Van Den Berg L.H, Van Es M.A, Sapp P.C, Van Vught P.W.J, McKenna-Yasek D.M, Blauw H.M, Cho T.-J, Polak M, Shi L, Wills A.-M, Broom W.J, Ticozzi N, Silani V, Ozoguz A, Rodriguez-Leyva I, Veldink J.H, Ivinson A.J, Saris C.G.J, Hosler B.A, Barnes-Nessa A, Couture N, Wokke J.H.J, Kwiatkowski Jr. T.J, Ophoff R.A, Cronin S, Hardiman O, Diekstra F.P, Leigh P.N, Shaw C.E, Simpson C.L, Hansen V.K, Powell J.F, Corcia P, Salachas F, Heath S, Galan P, Georges F, Horvitz H.R, Lathrop M, Purcell S, Al-Chalabi A, Brown Jr. R.H, Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis, Proceedings of the National Academy of Sciences of the United States of America, 106, (22), 2009, p9004 - 9009
Van Es M.A, Veldink J.H, Saris C.G.J, Blauw H.M, Van Vught P.W.J, Birve A, Lemmens R, Schelhaas H.J, Groen E.J.N, Huisman M.H.B, Van Der Kooi A.J, De Visser M, Dahlberg C, Estrada K, Rivadeneira F, Hofman A, Zwarts M.J, Van Doormaal P.T.C, Rujescu D, Strengman E, Giegling I, Muglia P, Tomik B, Slowik A, Uitterlinden A.G, Hendrich C, Waibel S, Meyer T, Ludolph A.C, Glass J.D, Purcell S, Cichon S, Nöthen M.M, Wichmann H.-E, Schreiber S, Vermeulen S.H.H.M, Kiemeney L.A, Wokke J.H.J, Cronin S, McLaughlin R.L, Hardiman O, Fumoto K, Pasterkamp R.J, Meininger V, Melki J, Leigh P.N, Shaw C.E, Landers J.E, Al-Chalabi A, Brown R.H, Robberecht W, Andersen P.M, Ophoff R.A, Van Den Berg L.H, Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis, Nature Genetics, 41, (10), 2009, p1083 - 1087
Phukan J, Hardiman O, The management of amyotrophic lateral sclerosis., Journal of neurology, 256, (2), 2009, p176-86
Van Es M.A, Van Vught P.W.J, Veldink J.H, Andersen P.M, Birve A, Lemmens R, Cronin S, Van Der Kooi A.J, De Visser M, Schelhaas H.J, Hardiman O, Ragoussis I, Lambrechts D, Robberecht W, Wokke J.H.J, Ophoff R.A, Van Den Berg L.H, Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis, 10, (5-6), 2009, p441 - 447
O'Sullivan E.P, Behan L.-A, King T.F.J, Hardiman O, Smith D, A case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis, Clinical Neurology and Neurosurgery, 111, (4), 2009, p384 - 386
Fallis B.A, Hardiman O, Aggregation of neurodegenerative disease in ALS kindreds, Amyotrophic Lateral Sclerosis, 10, (2), 2009, p95 - 98
Mohammad A.F, Khan K.A, Galvin L, Hardiman O, O'Connell P.G, High incidence of osteoporosis and fractures in an aging post-polio population, European Neurology, 62, (6), 2009, p369 - 374
O'Connor G, King M, Salomons G, Jakobs C, Hardiman O, A novel mutation as a cause of L-2-hydroxyglutaric aciduria, Journal of Neurology, 256, (4), 2009, p672 - 673
Cronin, S, Tomik, B, Bradley, DG, Slowik, A, Hardiman, O, Screening for replication of genome-wide SNP associations in sporadic ALS., European journal of human genetics : EJHG, 17, (2), 2009, p213 - 218
Meisler M.H, Russ C, Montgomery K.T, Greenway M, Ennis S, Hardiman O, Figlewicz D.A, Quenneville N.R, Conibear E, Brown Jr. R.H, Evaluation of the Golgi trafficking protein VPS54 (wobbler) as a candidate for ALS, Amyotrophic Lateral Sclerosis, 9, (3), 2008, p141 - 148
Hardiman O, A new editor for the "black but not bleak" journal - ALS research is coming of age, Amyotrophic Lateral Sclerosis, 9, (1), 2008, p3-
Cronin, S, Blauw, HM, Veldink, JH, van Es, MA, Ophoff, RA, Bradley, DG, van den Berg, LH, Hardiman, O, Analysis of genome-wide copy number variation in Irish and Dutch ALS populations., Human molecular genetics, 17, (21), 2008, p392-8
Meldrum D, Cahalane E, Conroy R, Fitzgerald D, Hardiman O, Erratum: Maximum voluntary isometric contraction: Reference values and clinical application (Amyotrophic Lateral Sclerosis (2007) vol. 8 (47-55)), Amyotrophic Lateral Sclerosis, 9, (1), 2008, p63-
Del Barco D.G, Berlanga Acosta J, Penton Arias E, Hardiman O, Montero E, Boosting controlled autoimmunity: A new therapeutic target for CNS disorders, Expert Review of Neurotherapeutics, 8, (5), 2008, p819 - 825
O'Toole O, Traynor B.J, Brennan P, Sheehan C, Frost E, Corr B, Hardiman O, Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004, Journal of Neurology, Neurosurgery and Psychiatry, 79, (1), 2008, p30 - 32
Broom W.J, Greenway M, Sadri-Vakili G, Russ C, Auwarter K.E, Glajch K.E, Dupre N, Swingler R, Purcell S, Hayward C, Sapp P, McKenna-Yasek D, Valdmanis P, Bouchard J.-P, Meininger V, Hosler B.A, Glass J, Polack M, Rouleau G, Cha J.-H, Hardiman O, Brown Jr. R, 50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis, 9, (4), 2008, p229 - 237
Kollewe K, Andersen P.M, Borasio G.D, Hardiman O, Leigh P.N, Pradat P.F, Silani V, Tomik B, Dengler R, Good practice in the management of amyotrophic lateral sclerosis: Clinical guidelines. An evidence-based review with good practice points from the EALSC working group, Nervenheilkunde, 27, (4), 2008, p302 - 316
Cronin, S, Berger, S, Ding, J, Schymick, JC, Washecka, N, Hernandez, DG, Greenway, MJ, Bradley, DG, Traynor, BJ, Hardiman, O, A genome-wide association study of sporadic ALS in a homogenous Irish population., Human molecular genetics, 17, (5), 2008, p768-74
Chiò A, Traynor B.J, Swingler R, Mitchell D, Hardiman O, Mora G, Beghi E, Logroscino G, Amyotrophic lateral sclerosis and soccer: A different epidemiological approach strengthen the previous findings, Journal of the Neurological Sciences, 269, (1-2), 2008, p187 - 188
Donaghy C, Dick A, Hardiman O, Patterson V, Timeliness of diagnosis in Motor Neurone Disease: A population-based study, Ulster Medical Journal, 77, (1), 2008, p18 - 21
Meldrum D, Cahalane E, Conroy R, Fitzgerald D, Hardiman O, Maximum voluntary isometric contraction: Reference values and clinical application, Amyotrophic Lateral Sclerosis, 8, (1), 2007, p47 - 55
Schymick J.C, Yang Y, Andersen P.M, Vonsattel J.P, Greenway M, Momeni P, Elder J, Chiò A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli R.J, Hutton M, Gass J, Cannon A, Rademakers R, Singleton A.B, Hardiman O, Rothstein J, Hardy J, Traynor B.J, Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes, Journal of Neurology, Neurosurgery and Psychiatry, 78, (7), 2007, p754 - 756
McKeon A, Ozelius L.J, Hardiman O, Greenway M.J, Pittock S.J, Heterogeneity of presentation and outcome in the Irish rapid-onset dystonia-Parkinsonism kindred, Movement Disorders, 22, (9), 2007, p1325 - 1327
Hardiman O, Greenway M, The complex genetics of amyotrophic lateral sclerosis, Lancet Neurology, 6, (4), 2007, p291 - 292
Ryan A.M, Ryan J, Wan-Ahmed M, Hardiman O, Farrell M.A, McNamara B, Sweeney B.J, Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease [1], Journal of Neurology, Neurosurgery and Psychiatry, 78, (1), 2007, p98 - 99
Logroscino G, Beghi E, Hardiman O, Chio A, Mitchell J.D, Swingler R.J, Traynor B, Effect of referral bias on assessing survival in ALS [5], Neurology, 69, (9), 2007, p939-
Hosback S, Hardiman O, Nolan C.M, Doyle M.A.C, Gorman G, Lynch C, O'Toole O, Jakeman P, Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis, Growth Hormone and IGF Research, 17, (6), 2007, p472 - 479
Beghi E, Mennini T, Bendotti C, Bigini P, Logroscino G, Chiò A, Hardiman O, Mitchell D, Swingler R, Traynor B.J, Al-Chalabi A, The heterogeneity of amyotrophic lateral sclerosis: A possible explanation of treatment failure, Current Medicinal Chemistry, 14, (30), 2007, p3185 - 3200
Phukan J, Pender N.P, Hardiman O, Cognitive impairment in amyotrophic lateral sclerosis, Lancet Neurology, 6, (11), 2007, p994 - 1003
Foley G, O'Mahony P, Hardiman O., Perceptions of quality of life in people with ALS: effects of coping and health care, Amyotrophic Lateral Sclerosis, 8, (3), 2007, p164 - 169
Cronin S, Greenway M.J, Prehn J.H.M, Hardiman O, Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis, Journal of Neurology, Neurosurgery and Psychiatry, 78, (9), 2007, p984 - 986
Hardiman O, Cronin S, Traynor B.J, Reply from the authors [8], Neurology, 69, (7), 2007, p711 - 712
O'Sullivan P.J, Gorman G.M, Hardiman O.M, Farrell M.J, Logan P.M, Sonographically guided percutaneous muscle biopsy in diagnosis of neuromuscular disease: A useful alternative to open surgical biopsy, Journal of Ultrasound in Medicine, 25, (1), 2006, p1 - 6
Parkinson N, Ince P.G, Smith M.O, Highley R, Skibinski G, Andersen P.M, Morrison K.E, Pall H.S, Hardiman O, Collinge J, Shaw P.J, Fisher E.M.C, ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B), Neurology, 67, (6), 2006, p1074 - 1077
Greenway M.J, Andersen P.M, Russ G, Ennis S, Cashman S, Donaghy C, Patterson V, Swingler R, Kieran D, Prehn J, Morrison K.E, Green A, Acharya K.R, Brown Jr. R.H, Hardiman O, ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis, Nature Genetics, 38, (4), 2006, p411 - 413
Momeni P, Schymick J, Jain S, Cookson M.R, Cairns N.J, Greggio E, Greenway M.J, Berger S, Pickering-Brown S, Chiò A, Fung H.C, Holtzman D.M, Huey E.D, Wassermann E.M, Adamson J, Hutton M.L, Rogaeva E, St. George-Hyslop P, Rothstein J.D, Hardiman O, Grafman J, Singleton A, Hardy J, Traynor B.J, Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD, BMC Neurology, 6, 2006
Beghi E, Logroscino G, Chiò A, Hardiman O, Mitchell D, Swingler R, Traynor B.J, The epidemiology of ALS and the role of population-based registries, Biochimica et Biophysica Acta - Molecular Basis of Disease, 1762, (11-12), 2006, p1150 - 1157
Morgan R.K, McNally S, Alexander M, Conroy R, Hardiman O, Costello R.W, Use of sniff nasal-inspiratory force to predict survival in amyotrophic lateral sclerosis, American Journal of Respiratory and Critical Care Medicine, 171, (3), 2005, p269 - 274
ZaldÃvar T, Montejo Y, Acevedo A.M, Guerra R, Vargas J, Garofalo N, Alvarez R, Alvarez M.A, Hardiman O, Evidence of reduced frequency of spinal muscular atrophy type I in the Cuban population, Neurology, 65, (4), 2005, p636 - 638
Cahill C.M, Hardiman O, Murphy K.C, Treatment of refractory chronic daily headache with the atypical antipsychotic ziprasidone - A case series, Cephalalgia, 25, (10), 2005, p822 - 826
Kidney D, Alexander M, Corr B, O'Toole O, Hardiman O, Oropharyngeal dysphagia in amyotrophic lateral sclerosis: Neurological and dysphagia specific rating scales, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 5, (3), 2004, p150 - 153
O'Doherty L.J, Mickey A, Hardiman O, Quality of life in neurological illness: Generic versus individualised indicators, Psychology and Health, 19, (SUPPL. 1), 2004, p124-
Hardiman O, Hickey A, O'Donerty L.J, Physical decline and quality of life in amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 5, (4), 2004, p230 - 234
Meldrum D, Pittock S.J, Hardiman O, Ni Dhuill C, O'Regan M, Moroney J.T, Recovery of the upper limb post ischaemic stroke and the predictive value of the Orpington Prognostic Score, Clinical Rehabilitation, 18, (6), 2004, p694 - 702
Sattin J.A, Login I.S, Cassidy E.M, Hardiman O, Dinan T, O'Keane V, Buspirone challenge is not a valid probe of central 5-HT1A receptor function (multiple letters), Cephalalgia, 24, (6), 2004, p510 - 512
Pittock S.J, Meldrum D, Hardiman O, Thornton J, Brennan P, Moroney J.T, The Oxfordshire Community Stroke Project Classification: Correlation with imaging, associated complications, and prediction of outcome in acute ischemic stroke, Journal of Stroke and Cerebrovascular Diseases, 12, (1), 2003, p1 - 7
Pittock S.J, Meldrum D, Dhuill C.N, Hardiman O, Moroney J.T, The Orpington Prognostic Scale Within the First 48 Hours of Admission as a Predictor of Outcome in Ischemic Stroke, Journal of Stroke and Cerebrovascular Diseases, 12, (4), 2003, p175 - 181
Hardiman O, Corr B, Frost E, Gibbons P, Mahon L, Traynor B.J, Access to health services in Ireland for people with Multiple Sclerosis and Motor Neurone Disease., Irish medical journal, 96, (7), 2003, p200 - 203
Cassidy EM, Tomkins E, Hardiman O, O'Keane V, Factors associated with burden of primary headache in a specialty clinic., Headache, 43, (6), 2003, p638-44
Traynor B.J, Alexander M, Corr B, Frost E, Hardiman O, Effect of a multidisciplinary amyotrophic lateral sclerosis (ALS) clinic on ALS survival: A population based study, 1996-2000, Journal of Neurology, Neurosurgery and Psychiatry, 74, (9), 2003, p1258 - 1261
Browne L, Hardiman O, O'Dwyer H, Farrell M, Intracranial giant cell arteritis with fatal middle cerebral artery territory infarct, Clinical Neuropathology, 22, (4), 2003, p199 - 203
Cassidy EM, Tomkins E, Sharifi N, Dinan T, Hardiman O, O'Keane V, Differing central amine receptor sensitivity in different migraine subtypes? A neuroendocrine study using buspirone., Pain, 101, (3), 2003, p283-90
Meldrum D, Cahalane E, Keogan F, Hardiman O, Maximum voluntary isometric contraction: Investigation of reliability and learning effect, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 4, (1), 2003, p36 - 44
Ryan A, Nor A.M, Costigan D, Foley-Nolan D, El-Rafie A, Farrell M.A, Hardiman O, Polymyositis masquerading as motor neuron disease, Archives of Neurology, 60, (7), 2003, p1001 - 1003
Galvin C.D, Hardiman O, Nolan C.M, IGF-1 receptor mediates differentiation of primary cultures of mouse skeletal myoblasts, Molecular and Cellular Endocrinology, 200, (1-2), 2003, p19 - 29
Cassidy EM, Tomkins E, Dinan T, Hardiman O, O'Keane V, Central 5-HT receptor hypersensitivity in migraine without aura., Cephalalgia : an international journal of headache, 23, (1), 2003, p29-34
Norquist J.M, Jenkinson C, Fitzpatrick R, Swash M, Aarli J.A, Burgunder J.-M, Evangelista T, Fitzpatrick R, Genthon R, Hardiman O, Illa I, Jenkinson C, Leigh P.N, Ludin H.-P, Mazzini L, Meininger V, Mora J.S, Ortega M, Papapetropoulos T, Peto V, Pongratz D, Pouget J, Robberecht W, Ronnevi L.-O, Sales-Luis M, Silani V, Swash M, Wokke J.H.J, Werdelin L, Zierz S, Factors which predict physical and mental health status in patients with amyotrophic lateral sclerosis over time, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 4, (2), 2003, p112 - 117
Thornton F.J, Fotheringham T, Alexander M, Hardiman O, McGrath F.P, Lee M.J, Amyotrophic lateral sclerosis: Enteral nutrition provision - Endoscopic or radiologic gastrostomy?, Radiology, 224, (3), 2002, p713 - 717
Lee R.Z, Hardiman O, O'Connell P.G, Ibuprofen-induced aseptiv meningoencephalitis [7], Rheumatology, 41, (3), 2002, p353 - 355
Pongratz D, Zierz S, Fischer W, Jenkinson C, Fitzpatrick R, Peto V, Swash M, Aarli J.A, Burgunder J.-M, Evangelista T, Genthon R, Hardiman O, Illa I, Leigh P.N, Ludin H.-P, Mazzini L, Meininger V, Mora J.S, Ortega M, Papapetropoulos T, Pouget J, Robberecht W, Ronnevi L.-O, Sales-Luis M, Silani V, Wokke J.H.J, Werdelin L, Validity and reliability of the German language SF-36 health survey in patients with amyotrophic lateral sclerosis, Nervenheilkunde, 21, (8), 2002, p432 - 437
Hardiman O, Traynor B.J, Corr B, Frost E, Models of care for motor neuron disease: Setting standards, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 3, (4), 2002, p182 - 185
Pittock S.J, Meldrum D, Hardiman O, The "spray can" sign: Validation of a clinical observation in chronic inflammatory demyelinating polyneuropathy, Archives of Neurology, 59, (10), 2002, p1637 - 1640
Pittock S.J, Hardiman O, Goode B, Moroney J.T, Evaluation of stroke management in an Irish university teaching hospital: The Royal College of Physicians stroke audit package, Irish Journal of Medical Science, 170, (3), 2001, p163 - 168
Pittock S.J, Keir G, Alexander M, Brennan P, Hardiman O, Rapid clinical and CSF response to intravenous gamma globulin in acute disseminated encephalomyelitis [1], European Journal of Neurology, 8, (6), 2001, p725-
Borasio G.D, Shaw P.J, Hardiman O, Ludolph A.C, Sales Luis M.L, Silani V, Standards of palliative care for patients with amyotrophic lateral sclerosis: Results of a European survey, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2, (3), 2001, p159 - 164
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration , Orla Hardiman , [eds.]
Non-Peer-Reviewed Publications
Hutchinson M, Galvin R, Sweeney B, Lynch T, Murphy R, Redmond J, Traynor B.J, Hardiman O, Effect of a multidisciplinary clinic on survival in amyotrophic lateral sclerosis [2] (multiple letters), Journal of Neurology, Neurosurgery and Psychiatry, 75, (8), 2004, p1208 - 1209
Research Expertise
Description
Epidemiology, genetics and deep phenotyping of Amyotrophic Lateral Sclerosis: Health Services Research; Drug development and Clinical TrialsProjects
- Title
- Deep Phenotyping & Complex Genetics of ALS: A Multidisciplinary Population Based Approach
- Summary
- Characterization of epidemiology, genetics and phenotype of ALS/MND in Ireland
- Funding Agency
- Health Research Board
- Date From
- 2007
- Date To
- 2017
- Title
- Living and Dying with Amyotrophic Lateral Sclerosis: A Population based Analysis of Palliative Needs, Services and Outcomes in Non-malignant Terminal Illness
- Summary
- Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease. 70% of those with ALS die within 1000 days of their first symptom. Up to 50% of patients with ALS develop a degree of cognitive impairment, and 15 % develop a full-blown fronto-temporal dementia. There are currently no effective disease modifying therapies for ALS, and clinical intervention is focused on enhancing the quality of life for patients and relatives by relieving symptoms, providing emotional, psychological and spiritual support as needed, nd supporting the family in bereavement. As is the case for all neurodegenerative diseases, the generation of management protocols for ALS are more complex than for monophasic illnesses. This complexity relates to the multi-dimensionality and interdependence of required service provision. By extension, outcomes measurements must also be recognized as being multidimensional and interdependent. Notwithstanding their complexity, the design and availability of tools to determine and measure outcome in neurodegenerative conditions like ALS are of considerable importance. Such tools can be incorporated into the inception of integrated framework models of palliative care that can be planned, implemented, evaluated and reassessed. Design of such a framework requires detailed clinical information, drawn from a population based source that can then be validated in an incident based cohort monitored prospectively. As new disease modifying therapies become available, there is also an evolving need to identify key clinical milestones representing stages of ALS, to measure differences in resource utilization, and to define methods by which quality of life is measured across disease stages. These data are important for pharmaco-economic analyses of new therapeutics, and accurate analysis of these factors is also essential to the generation and monitoring of evidence based care pathway. This process is feasible in Ireland, as a national Register of ALS was established in 1995, and details of all incident cases (>1400) of ALS in the Republic of Ireland have been collected since then. Over 80% of all cases now attend the National ALS Centre in Beaumont Hospital. Retrospective data mining of the Register can provide important information about changes in incidence prevalence and natural history of the disease, the timing benefits and outcome of interventions including non-invasive ventilation and gastrostomy insertion; the beneficial effect of attending a multidisciplinary clinic, and the effects of cognitive impairment on prognosis and outcome. More detailed analysis from the more extensive clinic-based datasets can enrich the Register-based data to capture interactions with clinical professionals and the provision of equipment, and can incorporate phenotypic data including the presence and severity of cognitive impairment. These data can generate and validate prognostic indicators in ALS, from which a previously published staging algorithm can be replicated and validated. Prospective cohort analysis can then best used to generate and validate a framework of multidisciplinary intervention, including the appropriate intervention of general and specialist palliative care services The completed project will provide a best practice framework for future management of neurodegenerative disease, including an embedded rating scale that will trigger specialist palliative intervention in accordance with recent Irish health policy. The multidisciplinary research consortium comprises 6 key researchers from different fields, each with an established track record in their field of expertise, which include clinical care, population health , health services research and health economics. The research programme will be organised in three specific and interlinked work packages, spanning clinical, epidemiological and health services research including health economics.
- Funding Agency
- Health Research Board
- Date From
- 2013
- Date To
- 2016
- Title
- Test project
Recognition
Awards and Honours
International Alliance of ALS/MND Forbes Norris Award
Sheila Essey Award, American Academy of Neuroloy
American Academy of Neurology Palatucci Advocacy Award
Elected Member, Royal Irish Academy
Memberships
Member Royal Irish Academy
Fellow, Trinity College Dublin
Fellow of the Royal College of Physicians in Ireland
Fellow of the American Academy of Neurology
Fellow of the American Neurological Association